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Tbio
PRND
Prion-like protein doppel

Protein Summary
Description
Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (PubMed:15218028, PubMed:20411530). This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305817
  • ENSP00000306900
  • ENSG00000171864

Symbol
  • DPL
  • DPL
  • PrPLP
  • DOPPEL
  • dJ1068H6.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.65
cell type or tissue
0.6
transcription factor
0.54
transcription factor binding site profile
0.52
PubMedID
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.61   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.61   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (104)
SPRN
Tbio
Novelty:  0.02906105
Score:  0.979
Data Source:  STRINGDB
NEGR1
Tbio
Novelty:  0.0088917
Score:  0.919
Data Source:  STRINGDB
LY6K
Tbio
Novelty:  0.01861325
Score:  0.908
Data Source:  STRINGDB
GPLD1
Tbio
Family:  Enzyme
Novelty:  0.00627091
Score:  0.907
Data Source:  STRINGDB
IZUMO1R
Tbio
Novelty:  0.02670576
Score:  0.906
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.905
Data Source:  STRINGDB
LYPD1
Tbio
Novelty:  0.10740408
Score:  0.9
Data Source:  STRINGDB
PRSS21
Tbio
Family:  Enzyme
Novelty:  0.0110251
Score:  0.9
Data Source:  STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
Score:  0.9
Data Source:  STRINGDB
RECK
Tbio
Novelty:  0.00409224
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sporadic Creutzfeld Jacob disease
2
2
0
1.3
79.2
DNA methylation
1
1
1
49.5
KANNO antigen measurement
1
1
0
1060
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sporadic Creutzfeld Jacob disease
0
1.3
79.2
DNA methylation
1
49.5
KANNO antigen measurement
0
1060
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1346999
26434
Rat
RGD:1306618
113910
Dog
prion like protein doppel
VGNC:45003
485782
Horse
prion like protein doppel
VGNC:21867
100048937
Cow
prion like protein doppel
VGNC:33355
281426
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
prion like protein doppel
Horse
prion like protein doppel
Cow
prion like protein doppel
Publication Statistics
PubMed Score 191.61
PubMed score by year
PubTator Score 118.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title