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Tchem
PRMT8
Protein arginine N-methyltransferase 8

Protein Summary
Description
S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585). Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382622
  • ENSP00000372067
  • ENSG00000111218
  • ENST00000452611
  • ENSP00000414507

Symbol
  • HRMT1L3
  • HRMT1L4
  • HRMT1L3
  • HRMT1L4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
molecular function
0.73
cell line
0.61
PubMedID
0.61
transcription factor binding site profile
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.77   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.77   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (25)
MS023
Rendered image for MS023
MS049
Rendered image for MS049
CHEMBL4094513
Rendered image for CHEMBL4094513
CHEMBL4463793
Rendered image for CHEMBL4463793
CHEMBL3970878
Rendered image for CHEMBL3970878
CHEMBL3589030
Rendered image for CHEMBL3589030
CHEMBL3589026
Rendered image for CHEMBL3589026
CHEMBL3589031
Rendered image for CHEMBL3589031
CHEMBL3589028
Rendered image for CHEMBL3589028
CHEMBL3589029
Rendered image for CHEMBL3589029
Protein-Protein Interactions (155)
HNRNPU
Tbio
Novelty:  0.00517939
p_int:  0.999961929
p_ni:  0.000038071
Score:  0.832
Data Source:  BioPlex,STRINGDB
PRMT1
Tchem
Family:  Epigenetic
Novelty:  0.0032916
p_int:  0.999952017
p_ni:  0.000047982
p_wrong:  1e-9
Score:  0.814
Data Source:  BioPlex,STRINGDB
HNRNPR
Tbio
Novelty:  0.06568708
p_int:  0.999453057
p_ni:  0.000546943
Score:  0.634
Data Source:  BioPlex,STRINGDB
ANGEL2
Tbio
Novelty:  0.26130802
p_int:  0.999004537
p_ni:  0.000995463
Score:  0.286
Data Source:  BioPlex,STRINGDB
LSM14A
Tbio
Novelty:  0.04728617
p_int:  0.997878003
p_ni:  0.002121997
Score:  0.549
Data Source:  BioPlex,STRINGDB
DHX9
Tbio
Family:  Enzyme
Novelty:  0.00130907
p_int:  0.99778099
p_ni:  0.00221901
Score:  0.441
Data Source:  BioPlex,STRINGDB
CHTOP
Tbio
Novelty:  0.04170391
p_int:  0.997608172
p_ni:  0.002391828
Score:  0.281
Data Source:  BioPlex,STRINGDB
FAM120A
Tbio
Novelty:  0.1054654
p_int:  0.995180858
p_ni:  0.004819142
Score:  0.516
Data Source:  BioPlex,STRINGDB
SYNCRIP
Tbio
Novelty:  0.01479381
p_int:  0.994941764
p_ni:  0.005058236
Score:  0.814
Data Source:  BioPlex,STRINGDB
THRAP3
Tbio
Novelty:  0.0847559
p_int:  0.990890281
p_ni:  0.009109719
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
4
5
9.2
92.5
creatinine measurement
2
2
2
84.5
neutrophil count
1
1
1
51.7
leukocyte count
1
1
1
48.5
gut microbiome measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
9.2
92.5
creatinine measurement
2
84.5
neutrophil count
1
51.7
leukocyte count
1
48.5
gut microbiome measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein arginine methyltransferase 8
VGNC:5546
451758
Macaque
protein arginine methyltransferase 8
709826
Mouse
MGI:3043083
381813
Rat
RGD:1587677
688502
Dog
protein arginine methyltransferase 8
VGNC:45001
486740
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein arginine methyltransferase 8
Macaque
protein arginine methyltransferase 8
Mouse
Rat
Dog
protein arginine methyltransferase 8
Publication Statistics
PubMed Score 26.77
PubMed score by year
PubTator Score 13.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title