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Tchem
PRMT7
Protein arginine N-methyltransferase 7

Protein Summary
Description
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. This gene encodes a member of the protein arginine ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339507
  • ENSP00000343103
  • ENSG00000132600
  • ENST00000441236
  • ENSP00000409324
  • ENST00000449359
  • ENSP00000414716

Symbol
  • KIAA1933
  • SBIDDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.8
molecular function
0.76
biological process
0.72
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.6   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.6   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (59)
EIF2S2
Tbio
Novelty:  0.0146918
p_int:  0.999999744
p_ni:  2.7e-8
p_wrong:  2.28e-7
Score:  0.219
Data Source:  BioPlex,STRINGDB
THAP8
Tdark
Family:  TF
Novelty:  3.10152067
p_int:  0.999805583
p_ni:  0.000166063
p_wrong:  0.000028353
Score:  0.513
Data Source:  BioPlex,STRINGDB
SMAD7
Tbio
Family:  TF
Novelty:  0.00116343
p_int:  0.999800923
p_ni:  0.00019844
p_wrong:  6.37e-7
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.99962315
p_ni:  0.000101859
p_wrong:  0.000274991
Data Source:  BioPlex
TRMT2A
Tbio
Family:  Enzyme
Novelty:  0.15277091
p_int:  0.915642799
p_ni:  0.000186503
p_wrong:  0.084170698
Score:  0.298
Data Source:  BioPlex,STRINGDB
INHBE
Tbio
Novelty:  0.07526145
p_int:  0.890157488
p_ni:  0.000130802
p_wrong:  0.109711711
Score:  0.187
Data Source:  BioPlex,STRINGDB
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.84744057
p_ni:  0.000176846
p_wrong:  0.152382584
Score:  0.161
Data Source:  BioPlex,STRINGDB
PRMT5
Tchem
Family:  Epigenetic
Novelty:  0.00395474
Score:  0.918
Data Source:  STRINGDB
CTCFL
Tbio
Family:  TF
Novelty:  0.00858527
Score:  0.815
Data Source:  STRINGDB
PIK3CG
Tclin
Family:  Kinase
Novelty:  0.00170533
Score:  0.796
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
RMTs methylate histone arginines
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred by Curator (IC)
HGNC
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
3
91.8
high density lipoprotein cholesterol measurement
1
3
3
89.9
apolipoprotein A 1 measurement
1
3
3
88.7
glomerular filtration rate
4
3
3
6.4
77.8
metabolite measurement
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
91.8
high density lipoprotein cholesterol measurement
3
89.9
apolipoprotein A 1 measurement
3
88.7
glomerular filtration rate
3
6.4
77.8
metabolite measurement
1
70.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein arginine methyltransferase 7
702853
Mouse
MGI:2384879
214572
Rat
RGD:1304869
361402
Dog
protein arginine methyltransferase 7
VGNC:45000
479677
Horse
protein arginine methyltransferase 7
VGNC:21864
100066681
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein arginine methyltransferase 7
Mouse
Rat
Dog
protein arginine methyltransferase 7
Horse
protein arginine methyltransferase 7
Publication Statistics
PubMed Score 55.60
PubMed score by year
PubTator Score 24.51
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title