Tchem PRMT7 Protein arginine N-methyltransferase 7

Protein Summary

Description

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q9NVM4
• B3KPR0
• B3KUG9
• B4E379
• Q96PV5
• Q9H9L0

Gene Name

• PRMT7

Ensembl ID

• ENST00000339507
• ENSP00000343103
• ENSG00000132600
• ENST00000441236
• ENSP00000409324
• ENST00000449359
• ENSP00000414716

Symbol

• KIAA1933
• SBIDDS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor binding site profile	0.8
molecular function	0.76
biological process	0.72
tissue sample	0.7

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Writer / Protein Methyltransferase / Protein Arginine Methyltransferase / Protein Arginine N-methyltransferase 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.6   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.6   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GlyGen

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

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1 – 1 of 1

DS-437

PRMT7Tchem Epigenetic

pIC50 : 5.23

Protein-Protein Interactions (59)

Explore Interacting Targets

1 – 10 of 59

• See Interactions on String-DB

EIF2S2

Tbio

Novelty:  0.0146918

p_int:  0.999999744

p_ni:  2.7e-8

p_wrong:  2.28e-7

Score:  0.219

Data Source:  BioPlex,STRINGDB

THAP8

Tdark

Family:  TF

Novelty:  3.10152067

p_int:  0.999805583

p_ni:  0.000166063

p_wrong:  0.000028353

Score:  0.513

Data Source:  BioPlex,STRINGDB

SMAD7

Tbio

Family:  TF

Novelty:  0.00116343

p_int:  0.999800923

p_ni:  0.00019844

p_wrong:  6.37e-7

Data Source:  BioPlex

FAM19A3

Tdark

Novelty:  0.37183557

p_int:  0.99962315

p_ni:  0.000101859

p_wrong:  0.000274991

Data Source:  BioPlex

TRMT2A

Tbio

Family:  Enzyme

Novelty:  0.15277091

p_int:  0.915642799

p_ni:  0.000186503

p_wrong:  0.084170698

Score:  0.298

Data Source:  BioPlex,STRINGDB

INHBE

Tbio

Novelty:  0.07526145

p_int:  0.890157488

p_ni:  0.000130802

p_wrong:  0.109711711

Score:  0.187

Data Source:  BioPlex,STRINGDB

IQCN

Tdark

Novelty:  2.74045479

p_int:  0.84744057

p_ni:  0.000176846

p_wrong:  0.152382584

Score:  0.161

Data Source:  BioPlex,STRINGDB

PRMT5

Tchem

Family:  Epigenetic

Novelty:  0.00395474

Score:  0.918

Data Source:  STRINGDB

CTCFL

Tbio

Family:  TF

Novelty:  0.00858527

Score:  0.815

Data Source:  STRINGDB

PIK3CG

Tclin

Family:  Kinase

Novelty:  0.00170533

Score:  0.796

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Chromatin modifying enzymes (R-HSA-3247509)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	RMTs methylate histone arginines	49 targets	R-HSA-3214858

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
RMTs methylate histone arginines	49 targets	R-HSA-3214858

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (10)

Components (4)

Processes (9)

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GO Term	Evidence	Assigned by
[myelin basic protein]-arginine N-methyltransferase activity	Inferred from Direct Assay (IDA)	HGNC
histone-arginine N-methyltransferase activity	Inferred from Direct Assay (IDA)	HGNC
protein-arginine omega-N monomethyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein-arginine omega-N symmetric methyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
S-adenosylmethionine-dependent methyltransferase activity	Inferred from Direct Assay (IDA)	HGNC
ribonucleoprotein complex binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein-arginine omega-N asymmetric methyltransferase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
histone methyltransferase activity (H4-R3 specific)	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein-arginine N-methyltransferase activity	Traceable Author Statement (TAS)	Reactome
histone binding	Inferred by Curator (IC)	HGNC

Disease Associations ()

No disease associations found

GWAS Traits (22)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	2	2	3		91.8
high density lipoprotein cholesterol measurement	EFO_0004612	1	3	3		89.9
apolipoprotein A 1 measurement	EFO_0004614	1	3	3		88.7
glomerular filtration rate	EFO_0005208	4	3	3	6.4	77.8
metabolite measurement	EFO_0004725	1	1	1		70.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	3		91.8
high density lipoprotein cholesterol measurement	EFO_0004612	3		89.9
apolipoprotein A 1 measurement	EFO_0004614	3		88.7
glomerular filtration rate	EFO_0005208	3	6.4	77.8
metabolite measurement	EFO_0004725	1		70.5

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UniProt Keyword Find Similar Targets

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Alternative splicing
Chromatin regulator
Complete proteome
Cytoplasm
Differentiation
Disease mutation
Dwarfism
Mental retardation
Methylation
Methyltransferase

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
appendicular lean mass
birth weight
blood metabolite measurement
BMI-adjusted waist-hip ratio
body height
body mass index
cognitive function measurement
comparative body size at age 10, self-reported
creatinine measurement

MGI Phenotype Find Similar Targets

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cardiovascular system phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging
neoplasm

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	protein arginine methyltransferase 7		702853
Mouse	protein arginine N-methyltransferase 7	MGI:2384879	214572
Rat	protein arginine methyltransferase 7	RGD:1304869	361402
Dog	protein arginine methyltransferase 7	VGNC:45000	479677
Horse	protein arginine methyltransferase 7	VGNC:21864	100066681

Species	Name	OMA	EggNOG	Inparanoid
Macaque	protein arginine methyltransferase 7
Mouse	protein arginine N-methyltransferase 7
Rat	protein arginine methyltransferase 7
Dog	protein arginine methyltransferase 7
Horse	protein arginine methyltransferase 7

Publication Statistics

PubMed Score 55.60

PubMed score by year

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PubTator Score 24.51

PubTator score by year

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Related Publications

Text Mined References (25)

GeneRif Annotations (12)

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PMID	Year	Title