You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PRMT5
Protein arginine N-methyltransferase 5

Protein Summary
Description
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:21081503). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methyl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216350
  • ENSP00000216350
  • ENSG00000100462
  • ENST00000324366
  • ENSP00000319169
  • ENST00000397440
  • ENSP00000380582
  • ENST00000397441
  • ENSP00000380583
  • ENST00000553897
  • ENSP00000452555

Symbol
  • HRMT1L5
  • IBP72
  • JBP1
  • SKB1
  • HSL7
  • JBP1
  • SKB1
  • IBP72
  • SKB1Hs
  • HRMT1L5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
kinase perturbation
0.93
hub protein
0.92
histone modification site profile
0.9
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.33   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 574   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.33   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 574   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 317
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (317)
S-adenosylhomocysteine
Rendered image for S-adenosylhomocysteine
DS-437
Rendered image for DS-437
CHEMBL4518534
Rendered image for CHEMBL4518534
EPZ015666
Rendered image for EPZ015666
GSK591
Rendered image for GSK591
LLY-283
Rendered image for LLY-283
CHEMBL4441584
Rendered image for CHEMBL4441584
CHEMBL4249337
Rendered image for CHEMBL4249337
CHEMBL4541714
Rendered image for CHEMBL4541714
CHEMBL4543007
Rendered image for CHEMBL4543007
Protein-Protein Interactions (361)
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.999928797
p_ni:  0.000071204
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999908791
p_ni:  0.000091209
Score:  0.575
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.999323316
p_ni:  0.000676684
Score:  0.981
Data Source:  BioPlex,STRINGDB
FARP2
Tbio
Novelty:  0.09590913
p_int:  0.999149228
p_ni:  0.000850772
Data Source:  BioPlex
RPL15
Tbio
Novelty:  0.02466708
p_int:  0.997542487
p_ni:  0.002457513
Score:  0.413
Data Source:  BioPlex,STRINGDB
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.99692369
p_ni:  0.00307631
Score:  0.597
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.996819117
p_ni:  0.003180883
Score:  0.303
Data Source:  BioPlex,STRINGDB
CHTOP
Tbio
Novelty:  0.04170391
p_int:  0.996475616
p_ni:  0.003524385
Score:  0.571
Data Source:  BioPlex,STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.994899645
p_ni:  0.005100355
Score:  0.215
Data Source:  BioPlex,STRINGDB
CIRBP
Tbio
Novelty:  0.00439066
p_int:  0.994848274
p_ni:  0.005151726
Score:  0.264
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (36)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
2
6
96.1
reticulocyte measurement
3
2
3
94.7
reticulocyte count
4
2
4
94.3
self reported educational attainment
4
4
3
5.7
91
mathematical ability
4
3
4
86.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
96.1
reticulocyte measurement
3
94.7
reticulocyte count
4
94.3
self reported educational attainment
3
5.7
91
mathematical ability
4
86.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein arginine methyltransferase 5
VGNC:3352
452789
Macaque
protein arginine methyltransferase 5
712718
Mouse
MGI:1351645
27374
Rat
RGD:1309053
364382
Dog
protein arginine methyltransferase 5
VGNC:44998
480242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein arginine methyltransferase 5
Macaque
protein arginine methyltransferase 5
Mouse
Rat
Dog
protein arginine methyltransferase 5
Publication Statistics
PubMed Score 364.33
PubMed score by year
PubTator Score 172.28
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title