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Tchem
PRMT3
Protein arginine N-methyltransferase 3

Protein Summary
Description
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331079
  • ENSP00000331879
  • ENSG00000185238
  • ENST00000437750
  • ENSP00000397766

Symbol
  • HRMT1L3
  • HRMT1L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
transcription factor binding site profile
0.89
histone modification site profile
0.82
kinase perturbation
0.81
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.05   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.05   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (41)
S-adenosylhomocysteine
Rendered image for S-adenosylhomocysteine
MS023
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CHEMBL4094513
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CHEMBL4588797
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SGC707
Rendered image for SGC707
compound 1 [PMID: 22795084]
Rendered image for compound 1 [PMID: 22795084]
CHEMBL4079503
Rendered image for CHEMBL4079503
CHEMBL4076640
Rendered image for CHEMBL4076640
CHEMBL4061429
Rendered image for CHEMBL4061429
CHEMBL4077534
Rendered image for CHEMBL4077534
Protein-Protein Interactions (158)
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.999999938
p_ni:  6.2e-8
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
PDCD2
Tbio
Novelty:  0.05054811
p_int:  0.999998099
p_ni:  0.0000019
Score:  0.246
Data Source:  BioPlex,STRINGDB
PDCD2L
Tbio
Novelty:  0.33193498
p_int:  0.999996769
p_ni:  1.1e-8
p_wrong:  0.00000322
Score:  0.892
Data Source:  BioPlex,STRINGDB
STX19
Tdark
Novelty:  0.99387951
p_int:  0.999700022
p_ni:  0.000299978
Score:  0.176
Data Source:  BioPlex,STRINGDB
XXYLT1
Tbio
Family:  Enzyme
Novelty:  0.16837376
p_int:  0.999368112
p_ni:  0.000631875
p_wrong:  1.3e-8
Data Source:  BioPlex
GTF2IRD2B
Tbio
Family:  TF
Novelty:  0.14868633
p_int:  0.999244456
p_ni:  0.000755544
Data Source:  BioPlex
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
p_int:  0.994793474
p_ni:  0.005206516
p_wrong:  1e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
GMPPB
Tbio
Family:  Enzyme
Novelty:  0.05106206
p_int:  0.993323583
p_ni:  0.005882722
p_wrong:  0.000793695
Score:  0.311
Data Source:  BioPlex,STRINGDB
KLHL10
Tdark
Novelty:  0.09497583
p_int:  0.992658353
p_ni:  0.007341609
p_wrong:  3.8e-8
Score:  0.215
Data Source:  BioPlex,STRINGDB
TSKS
Tbio
Family:  Enzyme
Novelty:  0.0886446
p_int:  0.966366157
p_ni:  0.033632965
p_wrong:  8.79e-7
Score:  0.233
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Chromatin modifying enzymes (R-HSA-3247509)

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Find Similar Targets
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1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein methylation
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Metabolism of proteins
Post-translational protein modification
Protein methylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to alcohol
1
1
1
63.9
carotid artery intima media thickness
1
1
1
7.7
fractional shortening
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to alcohol
1
63.9
carotid artery intima media thickness
1
7.7
fractional shortening
1
2.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein arginine methyltransferase 3
VGNC:1040
451078
Macaque
protein arginine methyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:30163]
Mouse
MGI:1919224
71974
Rat
RGD:620413
89820
Dog
protein arginine methyltransferase 3
VGNC:44997
476887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein arginine methyltransferase 3
Macaque
protein arginine methyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:30163]
Mouse
Rat
Dog
protein arginine methyltransferase 3
Publication Statistics
PubMed Score 38.05
PubMed score by year
PubTator Score 25.37
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title