Tbio PRMT2 Protein arginine N-methyltransferase 2

Protein Summary

Description

Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.

Uniprot Accession IDs

• P55345
• B7U630
• B7U631
• B7U632
• P78350
• Q498Y5
• Q5U7D4
• Q6FHF0
• Q99781
• Q9BW15
• Q9UMC2

Gene Name

• PRMT2

Ensembl ID

• ENST00000291705
• ENSP00000291705
• ENSG00000160310
• ENST00000334494
• ENSP00000335490
• ENST00000355680
• ENSP00000347906
• ENST00000397637
• ENSP00000380759
• ENST00000397638
• ENSP00000380760
• ENST00000440086
• ENSP00000397266
• ENST00000451211
• ENSP00000411984
• ENST00000458387
• ENSP00000407463

Symbol

• HMT1
• HRMT1L1
• HRMT1L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
molecular function	0.97
kinase perturbation	0.96
transcription factor perturbation	0.88
biological process	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.5   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 419   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.5   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 419   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0