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Tbio
PRMT2
Protein arginine N-methyltransferase 2

Protein Summary
Description
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291705
  • ENSP00000291705
  • ENSG00000160310
  • ENST00000334494
  • ENSP00000335490
  • ENST00000355680
  • ENSP00000347906
  • ENST00000397637
  • ENSP00000380759
  • ENST00000397638
  • ENSP00000380760
  • ENST00000440086
  • ENSP00000397266
  • ENST00000451211
  • ENSP00000411984
  • ENST00000458387
  • ENSP00000407463

Symbol
  • HMT1
  • HRMT1L1
  • HRMT1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
molecular function
0.97
kinase perturbation
0.96
transcription factor perturbation
0.88
biological process
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.5   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 419   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.5   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 419   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0