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Tbio
PRMT2
Protein arginine N-methyltransferase 2

Protein Summary
Description
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291705
  • ENSP00000291705
  • ENSG00000160310
  • ENST00000334494
  • ENSP00000335490
  • ENST00000355680
  • ENSP00000347906
  • ENST00000397637
  • ENSP00000380759
  • ENST00000397638
  • ENSP00000380760
  • ENST00000440086
  • ENSP00000397266
  • ENST00000451211
  • ENSP00000411984
  • ENST00000458387
  • ENSP00000407463

Symbol
  • HMT1
  • HRMT1L1
  • HRMT1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
molecular function
0.97
kinase perturbation
0.96
transcription factor perturbation
0.88
biological process
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.43   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 419   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.43   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 419   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.999999957
p_ni:  4.3e-8
Data Source:  BioPlex
L3MBTL3
Tchem
Family:  Epigenetic
Novelty:  0.04659049
p_int:  0.999999915
p_ni:  8.3e-8
p_wrong:  2e-9
Score:  0.586
Data Source:  BioPlex,STRINGDB
FASLG
Tbio
Novelty:  0.0003303
p_int:  0.999999368
p_ni:  5.05e-7
p_wrong:  1.26e-7
Score:  0.167
Data Source:  BioPlex,STRINGDB
SHANK3
Tbio
p_int:  0.999987499
p_ni:  1.41e-7
p_wrong:  0.000012359
Data Source:  BioPlex
HTT
Tchem
Novelty:  0.00034051
p_int:  0.99993151
p_ni:  0.00006849
Score:  0.183
Data Source:  BioPlex,STRINGDB
SAMD1
Tdark
Novelty:  0.21956379
p_int:  0.999897933
p_ni:  0.000102067
Score:  0.589
Data Source:  BioPlex,STRINGDB
KSR1
Tbio
Family:  Kinase
Novelty:  0.00691155
p_int:  0.999851867
p_ni:  0.000145671
p_wrong:  0.000002462
Score:  0.201
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999537845
p_ni:  0.000462143
p_wrong:  1.2e-8
Data Source:  BioPlex
PSRC1
Tbio
Novelty:  0.02780308
p_int:  0.999407643
p_ni:  0.000038967
p_wrong:  0.00055339
Score:  0.258
Data Source:  BioPlex,STRINGDB
TIGD5
Tdark
Novelty:  1.93340494
p_int:  0.999147855
p_ni:  0.000852145
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
88.7
pulse pressure measurement
1
1
1
49.5
body mass index
1
1
1
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
88.7
pulse pressure measurement
1
49.5
body mass index
1
5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein arginine methyltransferase 2
VGNC:1132
458620
Macaque
protein arginine methyltransferase 2
708006
Mouse
MGI:1316652
15468
Rat
RGD:1565519
499420
Dog
protein arginine methyltransferase 2
VGNC:44996
480811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein arginine methyltransferase 2
Macaque
protein arginine methyltransferase 2
Mouse
Rat
Dog
protein arginine methyltransferase 2
Publication Statistics
PubMed Score 27.43
PubMed score by year
PubTator Score 16.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title