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Tchem
PRMT1
Protein arginine N-methyltransferase 1

Protein Summary
Description
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methyla ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391851
  • ENSP00000375724
  • ENSG00000126457
  • ENST00000454376
  • ENSP00000406162
  • ENST00000610806
  • ENSP00000484505

Symbol
  • HMT2
  • HRMT1L2
  • IR1B4
  • ANM1
  • HCP1
  • IR1B4
  • HRMT1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
hub protein
0.92
transcription factor binding site profile
0.9
transcription factor
0.89
interacting protein
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.41   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 509   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.41   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 509   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (28)
S-adenosylhomocysteine
Rendered image for S-adenosylhomocysteine
MS023
Rendered image for MS023
CHEMBL4463793
Rendered image for CHEMBL4463793
CHEMBL3589030
Rendered image for CHEMBL3589030
CHEMBL3589026
Rendered image for CHEMBL3589026
CHEMBL3589031
Rendered image for CHEMBL3589031
CHEMBL3589028
Rendered image for CHEMBL3589028
CHEMBL3589029
Rendered image for CHEMBL3589029
CHEMBL3589027
Rendered image for CHEMBL3589027
CHEMBL3589036,CHEMBL3589037
Rendered image for CHEMBL3589036,CHEMBL3589037
Protein-Protein Interactions (351)
PRMT8
Tchem
Family:  Epigenetic
Novelty:  0.04213384
p_int:  0.999952017
p_ni:  0.000047982
p_wrong:  1e-9
Score:  0.814
Data Source:  BioPlex,STRINGDB
CHTOP
Tbio
Novelty:  0.04170391
p_int:  0.997889087
p_ni:  0.002110913
Score:  0.707
Data Source:  BioPlex,STRINGDB
ERH
Tbio
Novelty:  0.00711649
p_int:  0.997683141
p_ni:  0.002316859
Score:  0.916
Data Source:  BioPlex,STRINGDB
TAF15
Tbio
Novelty:  0.0621505
p_int:  0.916430928
p_ni:  0.083569072
Score:  0.706
Data Source:  BioPlex,STRINGDB
CIRBP
Tbio
Novelty:  0.00439066
p_int:  0.890534848
p_ni:  0.109465152
Score:  0.429
Data Source:  BioPlex,STRINGDB
PRMT5
Tchem
Family:  Epigenetic
Novelty:  0.00395474
Score:  0.992
Data Source:  STRINGDB
BTG2
Tbio
Novelty:  0.00588584
Score:  0.982
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.977
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.972
Data Source:  STRINGDB
NCOA3
Tchem
Family:  Epigenetic
Novelty:  0.00193529
Score:  0.968
Data Source:  STRINGDB
Pathways (24)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Extra-nuclear estrogen signaling
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
ESR-mediated signaling
Estrogen-dependent gene expression
Extra-nuclear estrogen signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
6
6
97
serum albumin measurement
1
4
4
92.1
hemoglobin measurement
2
2
2
90.5
red blood cell density measurement
1
1
1
80.9
urate measurement
2
2
4
71.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
6
97
serum albumin measurement
4
92.1
hemoglobin measurement
2
90.5
red blood cell density measurement
1
80.9
urate measurement
4
71.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein arginine methyltransferase 1
719419
Mouse
MGI:107846
15469
Rat
RGD:62020
60421
Dog
protein arginine methyltransferase 1
VGNC:44995
476411
Horse
protein arginine methyltransferase 1
VGNC:21859
100052097
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein arginine methyltransferase 1
Mouse
Rat
Dog
protein arginine methyltransferase 1
Horse
protein arginine methyltransferase 1
Publication Statistics
PubMed Score 365.41
PubMed score by year
PubTator Score 212.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title