Protein Summary
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015]
- ENST00000241808
- ENSP00000241808
- ENSG00000122304
- ENST00000435245
- ENSP00000403681
- CT94.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.65 | ||
tissue | 0.52 | ||
co-expressed gene | 0.44 | ||
cell line | 0.42 | ||
PubMedID | 0.39 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 203.69 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 46 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 203.69 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 46 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
CHCHD2
Novelty: 0.01615338
p_int: 0.999997642
p_ni: 0.000002357
p_wrong: 1e-9
Data Source: BioPlex
PHF10
Family: Epigenetic
Novelty: 0.05941323
p_int: 0.999973537
p_ni: 0.000026463
Data Source: BioPlex
ZNF579
Family: TF
Novelty: 4.75515836
p_int: 0.999956812
p_ni: 0.000043187
p_wrong: 1e-9
Data Source: BioPlex
YY1AP1
Novelty: 0.06862573
p_int: 0.999845049
p_ni: 0.000154929
p_wrong: 2.2e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 4 | 4 | 4 | 90.9 | |||||
2 | 3 | 0 | 1.1 | 88.2 | |||||
reticulocyte measurement | 2 | 2 | 2 | 85.8 | |||||
mean corpuscular volume | 1 | 1 | 1 | 83.2 | |||||
2 | 2 | 0 | 1.1 | 78.7 | |||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte count | 4 | 90.9 | |||||
0 | 1.1 | 88.2 | |||||
reticulocyte measurement | 2 | 85.8 | |||||
mean corpuscular volume | 1 | 83.2 | |||||
0 | 1.1 | 78.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | protamine 2 | VGNC:5892 | 453921 | |||||
Macaque | protamine 2 | 711424 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | protamine 2 | |||||
Macaque | protamine 2 | |||||
Publication Statistics
PubMed Score 203.69
PubMed score by year
PubTator Score 115.68
PubTator score by year
Related Publications
Text Mined References (57)
GeneRif Annotations (26)
Items per page:
0 of 0
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