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Tbio
PRM2
Protamine-2

Protein Summary
Description
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241808
  • ENSP00000241808
  • ENSG00000122304
  • ENST00000435245
  • ENSP00000403681

Symbol
  • CT94.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.65
tissue
0.52
co-expressed gene
0.44
cell line
0.42
PubMedID
0.39


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.69   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.69   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
RBM27
Tdark
Novelty:  0.04875536
p_int:  0.999998079
p_ni:  0.000001921
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999997642
p_ni:  0.000002357
p_wrong:  1e-9
Data Source:  BioPlex
RBM23
Tbio
Novelty:  0.03769792
p_int:  0.999994662
p_ni:  0.000005338
Data Source:  BioPlex
PHF10
Tbio
Family:  Epigenetic
Novelty:  0.05941323
p_int:  0.999973537
p_ni:  0.000026463
Data Source:  BioPlex
ZNF579
Tdark
Family:  TF
Novelty:  4.75515836
p_int:  0.999956812
p_ni:  0.000043187
p_wrong:  1e-9
Data Source:  BioPlex
YY1AP1
Tbio
Novelty:  0.06862573
p_int:  0.999845049
p_ni:  0.000154929
p_wrong:  2.2e-8
Data Source:  BioPlex
LTV1
Tbio
Novelty:  0.04050879
p_int:  0.999832657
p_ni:  0.000167343
Data Source:  BioPlex
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999824386
p_ni:  0.000175614
Data Source:  BioPlex
SCAF4
Tbio
Novelty:  0.08174395
p_int:  0.999806599
p_ni:  0.000193401
Data Source:  BioPlex
ZNF638
Tbio
Novelty:  0.13248064
p_int:  0.999692853
p_ni:  0.000307147
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
4
4
4
90.9
2
3
0
1.1
88.2
reticulocyte measurement
2
2
2
85.8
mean corpuscular volume
1
1
1
83.2
2
2
0
1.1
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
4
90.9
0
1.1
88.2
reticulocyte measurement
2
85.8
mean corpuscular volume
1
83.2
0
1.1
78.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protamine 2
VGNC:5892
453921
Macaque
protamine 2
711424
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protamine 2
Macaque
protamine 2
Publication Statistics
PubMed Score 203.69
PubMed score by year
PubTator Score 115.68
PubTator score by year
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Related Publications
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PMID
Year
Title