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Tbio
PRLR
Prolactin receptor

Protein Summary
Description
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231423
  • ENSP00000231423
  • ENSG00000113494
  • ENST00000310101
  • ENSP00000309008
  • ENST00000348262
  • ENSP00000311613
  • ENST00000509140
  • ENSP00000425300
  • ENST00000511486
  • ENSP00000422556
  • ENST00000513753
  • ENSP00000424841
  • ENST00000514088
  • ENSP00000422935
  • ENST00000542609
  • ENSP00000441813
  • ENST00000618457
  • ENSP00000482954
  • ENST00000619676
  • ENSP00000484768
  • ENST00000620785
  • ENSP00000482689

Symbol
  • HPRL
  • MFAB
  • hPRLrI
  • RI-PRLR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
biological process
0.9
trait
0.86
gene perturbation
0.85
ligand (protein)
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 698.51   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 838   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 698.51   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 838   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0