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Tchem
PRLHR
Prolactin-releasing peptide receptor

Protein Summary
Description
Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing. PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239032
  • ENSP00000239032
  • ENSG00000119973
  • ENST00000636925
  • ENSP00000490073

Symbol
  • GPR10
  • GR3
  • GR3
  • GPR10
  • PrRPR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.9
ligand (protein)
0.68
phenotype
0.54
cell line
0.5
molecular function
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.29   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.29   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 128
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (19)
PRLH
Tdark
Novelty:  0.00663472
Score:  0.989
Data Source:  Reactome,STRINGDB
GRIP2
Tdark
Novelty:  0.0661318
Score:  0.779
Data Source:  STRINGDB
NPFF
Tbio
Novelty:  0.00489546
Score:  0.732
Data Source:  STRINGDB
QRFP
Tbio
Novelty:  0.02210773
Score:  0.713
Data Source:  STRINGDB
PICK1
Tbio
Novelty:  0.0058265
Score:  0.693
Data Source:  STRINGDB
GRIP1
Tbio
Novelty:  0.00343871
Score:  0.638
Data Source:  STRINGDB
NPVF
Tdark
Novelty:  0.01627922
Score:  0.542
Data Source:  STRINGDB
GPR150
Tdark
Family:  GPCR
Novelty:  0.91287003
Score:  0.528
Data Source:  STRINGDB
FAM19A5
Tdark
Novelty:  0.07792418
Score:  0.515
Data Source:  STRINGDB
OR6N2
Tdark
Family:  oGPCR
Novelty:  0.67142074
Score:  0.511
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Peptide ligand-binding receptors
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
8
comparative body size at age 10, self-reported
1
1
1
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
8
comparative body size at age 10, self-reported
1
3.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prolactin releasing hormone receptor
VGNC:5707
466259
Mouse
MGI:2135956
226278
Rat
RGD:71037
246075
Dog
prolactin releasing hormone receptor
VGNC:44993
486911
Horse
prolactin releasing hormone receptor
VGNC:21856
100066425
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prolactin releasing hormone receptor
Mouse
Rat
Dog
prolactin releasing hormone receptor
Horse
prolactin releasing hormone receptor
Publication Statistics
PubMed Score 18.29
PubMed score by year
PubTator Score 26.79
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title