Tchem PRLHR Prolactin-releasing peptide receptor

Protein Summary

Description

Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing. PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• P49683
• O75194
• Q502U8
• Q5VXR9
• PrRP receptor

Gene Name

• PRLHR

Ensembl ID

• ENST00000239032
• ENSP00000239032
• ENSG00000119973
• ENST00000636925
• ENSP00000490073

Symbol

• GPR10
• GR3
• GR3
• GPR10
• PrRPR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.9
ligand (protein)	0.68
phenotype	0.54
cell line	0.5
molecular function	0.49

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Prolactin-releasing Peptide Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.93   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.93   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 191

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0