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Tbio
PRL
Prolactin

Protein Summary
Description
Prolactin acts primarily on the mammary gland by promoting lactation. This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306482
  • ENSP00000302150
  • ENSG00000172179

Symbol
  • GHA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological term
0.91
gene perturbation
0.85
disease
0.8
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11487.14   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 1467   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11487.14   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 1467   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (310)
HLA-DQB2
Tbio
Novelty:  0.07062006
p_int:  0.994721686
p_ni:  0.004517483
p_wrong:  0.00076083
Score:  0.689
Data Source:  BioPlex,STRINGDB
PRLR
Tbio
Novelty:  0.00161982
Score:  0.999
Data Source:  Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.986
Data Source:  Reactome,STRINGDB
GH2
Tbio
Novelty:  0.00071871
Score:  0.984
Data Source:  Reactome,STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.983
Data Source:  Reactome,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.98
Data Source:  Reactome,STRINGDB
TRH
Tbio
Novelty:  0.00052673
Score:  0.965
Data Source:  STRINGDB
GHR
Tclin
Novelty:  0.00105635
Score:  0.962
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.961
Data Source:  STRINGDB
CSH1
Tbio
Novelty:  0.00100314
Score:  0.957
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (28)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Cytokine Signaling in Immune system
Reactome
Growth hormone receptor signaling
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Cytokine Signaling in Immune system
Growth hormone receptor signaling
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
2
3
90.5
myeloid white cell count
2
2
2
89.8
basophil percentage of leukocytes
2
2
2
86.2
neutrophil count
3
2
3
80.3
lymphocyte count
2
1
2
74.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
90.5
myeloid white cell count
2
89.8
basophil percentage of leukocytes
2
86.2
neutrophil count
3
80.3
lymphocyte count
2
74.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prolactin
VGNC:3671
462468
Macaque
prolactin
707052
Mouse
MGI:97762
19109
Rat
RGD:3403
24683
Dog
prolactin
VGNC:44992
488241
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prolactin
Macaque
prolactin
Mouse
Rat
Dog
prolactin
Publication Statistics
PubMed Score 11487.14
PubMed score by year
PubTator Score 8942.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title