Tbio PRL Prolactin

Protein Summary

Description

Prolactin acts primarily on the mammary gland by promoting lactation. This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P01236
• Q15199
• Q92996
• PRL

Gene Name

• PRL

Ensembl ID

• ENST00000306482
• ENSP00000302150
• ENSG00000172179

Symbol

• GHA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
biological term	0.91
gene perturbation	0.85
disease	0.8
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Prolactin

Protein / Signaling Molecule / Growth Factor / Prolactin

DTO Classes

Protein / Signaling / Growth Factor / Prolactin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12209.87   (req: < 5)

Gene RIFs: 280   (req: <= 3)

Antibodies: 1467   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12209.87   (req: >= 5)

Gene RIFs: 280   (req: > 3)

Antibodies: 1467   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0