Tbio PRKRIP1 PRKR-interacting protein 1

Protein Summary

Description

Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).

Uniprot Accession IDs

• Q9H875
• B4DGM2
• Q8NDM6
• Q96CF8

Gene Name

• PRKRIP1

Ensembl ID

• ENST00000397912
• ENSP00000381010
• ENSG00000128563
• ENST00000496391
• ENSP00000419270

Symbol

• C114
• KRBOX3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
histone modification site profile	0.93
transcription factor binding site profile	0.82
tissue	0.77
cellular component	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.95   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.95   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0