You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRKN
E3 ubiquitin-protein ligase parkin

Protein Summary
Description
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338468
  • ENSP00000343589
  • ENSG00000185345
  • ENST00000366894
  • ENSP00000355860
  • ENST00000366896
  • ENSP00000355862
  • ENST00000366897
  • ENSP00000355863
  • ENST00000366898
  • ENSP00000355865
  • ENST00000479615
  • ENSP00000434414

Symbol
  • PARK2
  • PDJ
  • AR-JP
  • LPRS2
  • PARK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1552.24   (req: < 5)
Gene RIFs: 545   (req: <= 3)
Antibodies: 717   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1552.24   (req: >= 5)
Gene RIFs: 545   (req: > 3)
Antibodies: 717   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 127
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0