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Tchem
PRKG1
cGMP-dependent protein kinase 1

Protein Summary
Description
Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via sever ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373980
  • ENSP00000363092
  • ENSG00000185532
  • ENST00000373985
  • ENSP00000363097
  • ENST00000401604
  • ENSP00000384200
  • ENST00000646535
  • ENSP00000493966

Symbol
  • PRKG1B
  • PRKGR1A
  • PRKGR1B
  • PKG
  • cGK
  • AAT8
  • PKG1
  • cGK1
  • cGKI
  • cGK 1
  • PRKG1B
  • PRKGR1B
  • cGKI-BETA
  • cGKI-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
molecular function
0.99
gene perturbation
0.89
hub protein
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 754.58   (req: < 5)
Gene RIFs: 94   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 754.58   (req: >= 5)
Gene RIFs: 94   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1