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Tchem
PRKD2
Serine/threonine-protein kinase D2

Protein Summary
Description
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291281
  • ENSP00000291281
  • ENSG00000105287
  • ENST00000433867
  • ENSP00000393978
  • ENST00000595515
  • ENSP00000470804
  • ENST00000600194
  • ENSP00000472744
  • ENST00000601806
  • ENSP00000469106

Symbol
  • PKD2
  • PKD2
  • HSPC187
  • nPKC-D2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
drug perturbation
0.99
disease perturbation
0.97
kinase
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.39   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 526   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.39   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 29
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0