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Tchem
PRKCQ
Protein kinase C theta type

Protein Summary
Description
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263125
  • ENSP00000263125
  • ENSG00000065675
  • ENST00000397176
  • ENSP00000380361
  • ENST00000539722
  • ENSP00000441752

Symbol
  • PRKCT
  • PRKCT
  • nPKC-theta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.99
hub protein
0.99
molecular function
0.96
gene perturbation
0.82


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.37   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 773   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.37   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 773   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 469
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2