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Tclin
PRKCD
Protein kinase C delta type

Protein Summary
Description
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330452
  • ENSP00000331602
  • ENSG00000163932
  • ENST00000394729
  • ENSP00000378217

Symbol
  • MAY1
  • PKCD
  • ALPS3
  • CVID9
  • nPKC-delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
disease perturbation
1
drug perturbation
1
hub protein
1


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1147.85   (req: < 5)
Gene RIFs: 402   (req: <= 3)
Antibodies: 1058   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1147.85   (req: >= 5)
Gene RIFs: 402   (req: > 3)
Antibodies: 1058   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 216
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (334)
NGEF
Tbio
Novelty:  0.04628547
p_int:  1
Score:  0.555
Data Source:  BioPlex,STRINGDB
EBI3
Tbio
Novelty:  0.09651194
p_int:  0.999999989
p_ni:  1e-8
Data Source:  BioPlex
PRKCB
Tchem
Family:  Kinase
Novelty:  0.00189802
Score:  0.975
Data Source:  STRINGDB
PRKCQ
Tchem
Family:  Kinase
Novelty:  0.00562719
Score:  0.974
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.973
Data Source:  STRINGDB
RACK1
Tbio
Novelty:  0.00200617
Score:  0.969
Data Source:  STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.966
Data Source:  STRINGDB
ELAVL1
Tchem
Novelty:  0.00110045
Score:  0.964
Data Source:  Reactome,STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.962
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.961
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (138)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (74)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
3
4
85.2
waist-hip ratio
1
6
6
81.2
BMI-adjusted waist-hip ratio
1
7
7
81.2
waist circumference
1
6
6
78.5
BMI-adjusted waist circumference
1
6
6
78.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
85.2
waist-hip ratio
6
81.2
BMI-adjusted waist-hip ratio
7
81.2
waist circumference
6
78.5
BMI-adjusted waist circumference
6
78.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C delta
VGNC:7105
460442
Macaque
protein kinase C delta
694656
Mouse
MGI:97598
18753
Rat
RGD:67383
170538
Dog
protein kinase C delta
VGNC:44979
494005
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C delta
Macaque
protein kinase C delta
Mouse
Rat
Dog
protein kinase C delta
Publication Statistics
PubMed Score 1147.85
PubMed score by year
PubTator Score 2317.53
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title