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Tchem
PRKCB
Protein kinase C beta type

Protein Summary
Description
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303531
  • ENSP00000305355
  • ENSG00000166501
  • ENST00000321728
  • ENSP00000318315
  • ENST00000643927
  • ENSP00000496129
  • ENST00000646168
  • ENSP00000493817

Symbol
  • PKCB
  • PRKCB1
  • PKCB
  • PRKCB1
  • PRKCB2
  • PKCI(2)
  • PKCbeta
  • PKC-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
protein domain
1
biological process
0.99
biological term
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 544.72   (req: < 5)
Gene RIFs: 182   (req: <= 3)
Antibodies: 805   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 544.72   (req: >= 5)
Gene RIFs: 182   (req: > 3)
Antibodies: 805   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 228
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2