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Tchem
PRKCA
Protein kinase C alpha type

Protein Summary
Description
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000413366
  • ENSP00000408695
  • ENSG00000154229

Symbol
  • PKCA
  • PRKACA
  • AAG6
  • PKCA
  • PRKACA
  • PKCI+/-
  • PKCalpha
  • PKC-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
pathway
1
protein domain
1


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1767.18   (req: < 5)
Gene RIFs: 435   (req: <= 3)
Antibodies: 1093   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1767.18   (req: >= 5)
Gene RIFs: 435   (req: > 3)
Antibodies: 1093   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 353
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (353)
staurosporine
Rendered image for staurosporine
G&ouml; 6976
Rendered image for G&ouml; 6976
CHEMBL2347053
Rendered image for CHEMBL2347053
balanol
Rendered image for balanol
7-hydroxystaurosporine
Rendered image for 7-hydroxystaurosporine
sotrastaurin
Rendered image for sotrastaurin
Bisindolylmaleimide I
Rendered image for Bisindolylmaleimide I
phorbol 12,13-dibutyrate
Rendered image for phorbol 12,13-dibutyrate
enzastaurin
Rendered image for enzastaurin
Protein-Protein Interactions (424)
PRKCB
Tchem
Family:  Kinase
Novelty:  0.00189802
p_int:  1
Score:  0.937
Data Source:  BioPlex,STRINGDB
PRKCG
Tchem
Family:  Kinase
Novelty:  0.00291817
p_int:  0.999999999
Score:  0.937
Data Source:  BioPlex,STRINGDB
PRKCH
Tchem
Family:  Kinase
Novelty:  0.01311926
p_int:  0.999975418
p_wrong:  0.000024582
Score:  0.939
Data Source:  BioPlex,STRINGDB
PIP5K1A
Tbio
Family:  Kinase
Novelty:  0.05039085
p_int:  0.99995138
p_ni:  0.00004862
Score:  0.151
Data Source:  BioPlex,STRINGDB
SHCBP1
Tbio
Novelty:  0.09160318
p_int:  0.999910888
p_ni:  0.000089112
Score:  0.179
Data Source:  BioPlex,STRINGDB
GCLM
Tbio
Family:  Enzyme
Novelty:  0.00395815
p_int:  0.99969649
p_ni:  0.000303016
p_wrong:  4.94e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
STARD7
Tbio
Novelty:  0.04511594
p_int:  0.99803782
p_ni:  0.001962058
p_wrong:  1.22e-7
Score:  0.18
Data Source:  BioPlex,STRINGDB
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.998020611
p_ni:  0.001979389
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.994292869
p_ni:  0.005707131
Data Source:  BioPlex
FGD4
Tbio
Novelty:  0.01920119
p_int:  0.937756172
p_ni:  3.76e-7
p_wrong:  0.062243451
Score:  0.351
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (15)
Explore Nearest Tclin Targets
1 – 4 of 4
ITGB7
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
ITGB3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  7
more:  3 more common pathways
ITGB1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
Pathways (258)
Acetylcholine regulates insulin secretion (R-HSA-399997)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 66
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine regulates insulin secretion
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca-dependent events
Reactome
Ca2+ pathway
Name
Explore in Pharos
Explore in Source
Acetylcholine regulates insulin secretion
Axon guidance
Beta-catenin independent WNT signaling
Ca-dependent events
Ca2+ pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (51)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (58)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
15
2
17
94.7
sex hormone-binding globulin measurement
9
2
8
10.3
92.4
triglyceride measurement
12
2
13
92.3
3
2
1
1.2
91.8
very low density lipoprotein cholesterol measurement
47
2
47
91.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
17
94.7
sex hormone-binding globulin measurement
8
10.3
92.4
triglyceride measurement
13
92.3
1
1.2
91.8
very low density lipoprotein cholesterol measurement
47
91.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C alpha
VGNC:12611
454832
Macaque
protein kinase C alpha
718412
Mouse
MGI:97595
18750
Rat
RGD:3395
24680
Dog
protein kinase C alpha
VGNC:44978
490904
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C alpha
Macaque
protein kinase C alpha
Mouse
Rat
Dog
protein kinase C alpha
Publication Statistics
PubMed Score 1767.18
PubMed score by year
PubTator Score 1710.48
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title