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Tchem
PRKAR2B
cAMP-dependent protein kinase type II-beta regulatory subunit

Protein Summary
Description
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265717
  • ENSP00000265717
  • ENSG00000005249
  • ENST00000639737
  • ENSP00000491687
  • ENSG00000284096

Symbol
  • PRKAR2
  • RII-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
molecular function
0.97
protein domain
0.92
gene perturbation
0.91
transcription factor perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.28   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 357   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.28   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (291)
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  1
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
p_int:  1
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
AKAP13
Tbio
Family:  Enzyme
Novelty:  0.00726267
p_int:  1
Score:  0.946
Data Source:  BioPlex,STRINGDB
PRKX
Tchem
Family:  Kinase
Novelty:  0.02599072
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.859
Data Source:  BioPlex,STRINGDB
CRYBG3
Tdark
Family:  Enzyme
Novelty:  0.24063491
p_int:  0.999999956
p_ni:  4.2e-8
p_wrong:  2e-9
Score:  0.192
Data Source:  BioPlex,STRINGDB
AKAP1
Tbio
Family:  Epigenetic
Novelty:  0.00437217
p_int:  0.999999839
p_ni:  1.61e-7
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
AKAP14
Tbio
Family:  Enzyme
Novelty:  0.50699923
p_int:  0.999999798
p_ni:  2.02e-7
Score:  0.807
Data Source:  BioPlex,STRINGDB
Q9P0M2
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.999999492
p_ni:  4.94e-7
p_wrong:  1.4e-8
Score:  0.502
Data Source:  BioPlex,STRINGDB
AKAP9
Tbio
Family:  Enzyme
Novelty:  0.0106532
p_int:  0.999998956
p_ni:  0.000001044
Score:  0.979
Data Source:  BioPlex,STRINGDB
AKAP5
Tbio
Family:  Enzyme
Novelty:  0.00351101
p_int:  0.999998633
p_ni:  2.5e-8
p_wrong:  0.000001342
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (82)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 50
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Aquaporin-mediated transport
Reactome
CREB1 phosphorylation through the activation of Adenylate Cyclase
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Activation of NMDA receptors and postsynaptic events
Anchoring of the basal body to the plasma membrane
Aquaporin-mediated transport
CREB1 phosphorylation through the activation of Adenylate Cyclase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
33.1
1
1
0
1.1
29
insomnia measurement
1
1
0
1
15.8
blood urea nitrogen measurement
1
1
1
7.7
triglyceride measurement
1
1
1
4.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
33.1
0
1.1
29
insomnia measurement
0
1
15.8
blood urea nitrogen measurement
1
7.7
triglyceride measurement
1
4.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase cAMP-dependent type II regulatory subunit beta
VGNC:14078
744011
Macaque
protein kinase cAMP-dependent type II regulatory subunit beta
700770
Mouse
MGI:97760
19088
Rat
RGD:3394
24679
Dog
protein kinase cAMP-dependent type II regulatory subunit beta
VGNC:44977
475887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase cAMP-dependent type II regulatory subunit beta
Macaque
protein kinase cAMP-dependent type II regulatory subunit beta
Mouse
Rat
Dog
protein kinase cAMP-dependent type II regulatory subunit beta
Publication Statistics
PubMed Score 223.28
PubMed score by year
PubTator Score 71.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title