Tchem PRKACG cAMP-dependent protein kinase catalytic subunit gamma

Protein Summary

Description

Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P22612
• O60850
• Q5VZ02
• Q86YI1
• PKA C-gamma

Gene Name

• PRKACG

Ensembl ID

• ENST00000377276
• ENSP00000366488
• ENSG00000165059

Symbol

• KAPG
• PKACg
• BDPLT19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
molecular function	0.93
protein domain	0.85
pathway	0.83
cell type or tissue	0.8

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Pka Family / Camp-dependent Protein Kinase Catalytic Subunit Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.19   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.19   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0