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Tchem
PRKACG
cAMP-dependent protein kinase catalytic subunit gamma

Protein Summary
Description
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377276
  • ENSP00000366488
  • ENSG00000165059

Symbol
  • KAPG
  • PKACg
  • BDPLT19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.93
protein domain
0.85
pathway
0.83
cell type or tissue
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.68   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.68   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (789)
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  1
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
p_int:  0.999998219
p_ni:  0.000001781
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
AKAP5
Tbio
Family:  Enzyme
Novelty:  0.00351101
p_int:  0.999996905
p_ni:  0.000002833
p_wrong:  2.62e-7
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
AKAP14
Tbio
Family:  Enzyme
Novelty:  0.50699923
p_int:  0.99996722
p_ni:  0.000032778
p_wrong:  3e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.999958659
p_ni:  0.000041341
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
AKAP9
Tbio
Family:  Enzyme
Novelty:  0.0106532
p_int:  0.998867271
p_ni:  0.001132729
Score:  0.973
Data Source:  BioPlex,STRINGDB
Q9P0M2
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.996835277
p_ni:  0.003164721
p_wrong:  2e-9
Score:  0.823
Data Source:  BioPlex,STRINGDB
GPR161
Tbio
Family:  GPCR
Novelty:  0.00235739
p_int:  0.996782661
p_ni:  0.003217132
p_wrong:  2.07e-7
Score:  0.979
Data Source:  BioPlex,STRINGDB
O43687
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.995091181
p_ni:  0.004418657
p_wrong:  0.000490162
Score:  0.823
Data Source:  BioPlex,STRINGDB
AKAP1
Tbio
Family:  Epigenetic
Novelty:  0.00437217
p_int:  0.994635083
p_ni:  0.005364917
Score:  0.973
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (54)
Explore Nearest Tclin Targets
1 – 5 of 6
ITGB1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
AR
Tclin
Family:  Nuclear Receptor
KEGG Distance:  1
Common Pathways:  2
Pathways (243)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 64
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Adaptive Immune System
Reactome
Aquaporin-mediated transport
Reactome
Axon guidance
Reactome
C-type lectin receptors (CLRs)
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Adaptive Immune System
Aquaporin-mediated transport
Axon guidance
C-type lectin receptors (CLRs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
1
1
39.6
Agents acting on the renin-angiotensin system use measurement
1
1
1
8.9
Headache
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
39.6
Agents acting on the renin-angiotensin system use measurement
1
8.9
Headache
1
2.6
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase cAMP-activated catalytic subunit gamma
VGNC:13947
472944
Macaque
protein kinase cAMP-activated catalytic subunit gamma
700652
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase cAMP-activated catalytic subunit gamma
Macaque
protein kinase cAMP-activated catalytic subunit gamma
Publication Statistics
PubMed Score 6.68
PubMed score by year
PubTator Score 5.97
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title