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Tchem
PRKACB
cAMP-dependent protein kinase catalytic subunit beta

Protein Summary
Description
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370682
  • ENSP00000359716
  • ENSG00000142875
  • ENST00000370685
  • ENSP00000359719
  • ENST00000370688
  • ENSP00000359722
  • ENST00000370689
  • ENSP00000359723
  • ENST00000394839
  • ENSP00000378315
  • ENST00000446538
  • ENSP00000401252
  • ENST00000610703
  • ENSP00000481980
  • ENST00000614872
  • ENSP00000479722

Symbol
  • PKACB
  • PKA C-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
hub protein
0.99
molecular function
0.98
pathway
0.93
histone modification site profile
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.96   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.96   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (818)
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  1
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
p_int:  0.999999993
p_ni:  7e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
GPR161
Tbio
Family:  GPCR
Novelty:  0.00235739
p_int:  0.999999242
p_ni:  7.58e-7
Score:  0.963
Data Source:  BioPlex,STRINGDB
Q9P0M2
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.99999896
p_ni:  0.000001018
p_wrong:  2.2e-8
Score:  0.606
Data Source:  BioPlex,STRINGDB
AKAP9
Tbio
Family:  Enzyme
Novelty:  0.0106532
p_int:  0.999998835
p_ni:  0.000001165
Score:  0.954
Data Source:  BioPlex,STRINGDB
AKAP11
Tbio
Family:  Enzyme
Novelty:  0.0685826
p_int:  0.999998035
p_ni:  0.000001965
Score:  0.706
Data Source:  BioPlex,STRINGDB
AKAP5
Tbio
Family:  Enzyme
Novelty:  0.00351101
p_int:  0.999997469
p_ni:  7.05e-7
p_wrong:  0.000001826
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
AKAP14
Tbio
Family:  Enzyme
Novelty:  0.50699923
p_int:  0.999980368
p_ni:  0.000019631
p_wrong:  1e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
PRKAR1B
Tbio
Family:  Enzyme
Novelty:  0.05355517
p_int:  0.999975872
p_ni:  0.000024121
p_wrong:  7e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
p_int:  0.999958659
p_ni:  0.000041341
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (54)
Explore Nearest Tclin Targets
1 – 5 of 6
ITGB1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
AR
Tclin
Family:  Nuclear Receptor
KEGG Distance:  1
Common Pathways:  2
Pathways (185)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Find Similar Targets
Items per page:
1 – 5 of 64
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Adaptive Immune System
Reactome
Aquaporin-mediated transport
Reactome
Axon guidance
Reactome
C-type lectin receptors (CLRs)
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Adaptive Immune System
Aquaporin-mediated transport
Axon guidance
C-type lectin receptors (CLRs)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
11.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
11.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase cAMP-activated catalytic subunit beta
VGNC:11804
469367
Macaque
protein kinase cAMP-activated catalytic subunit beta
709728
Mouse
MGI:97594
18749
Rat
RGD:1310574
293508
Dog
protein kinase cAMP-activated catalytic subunit beta
VGNC:44971
479975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase cAMP-activated catalytic subunit beta
Macaque
protein kinase cAMP-activated catalytic subunit beta
Mouse
Rat
Dog
protein kinase cAMP-activated catalytic subunit beta
Publication Statistics
PubMed Score 50.96
PubMed score by year
PubTator Score 20.23
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title