Tchem PRKACB cAMP-dependent protein kinase catalytic subunit beta

Protein Summary

Description

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• P22694
• B1APG4
• B4DKB0
• B4E2Q1
• Q14VH1
• Q59GC0
• Q5BNE9
• Q5BNF0
• Q5BNF1
• Q5BNF2
• Q5BNF3
• Q5CZ92
• Q5T1K3
• Q7Z3M1
• Q8IYR5
• Q8IZQ0
• Q96B09
• PKA C-beta

Gene Name

• PRKACB

Ensembl ID

• ENST00000370682
• ENSP00000359716
• ENSG00000142875
• ENST00000370685
• ENSP00000359719
• ENST00000370688
• ENSP00000359722
• ENST00000370689
• ENSP00000359723
• ENST00000394839
• ENSP00000378315
• ENST00000446538
• ENSP00000401252
• ENST00000610703
• ENSP00000481980
• ENST00000614872
• ENSP00000479722

Symbol

• PKACB
• PKA C-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
hub protein	0.99
molecular function	0.98
pathway	0.93
histone modification site profile	0.91

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Pka Family / Camp-dependent Protein Kinase Catalytic Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.96   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 374   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.96   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (6)

Dark Kinase Knowledgebase

The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.

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ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (3)

Explore Active Ligands

1 – 3 of 3

staurosporine

PRKACBTchem Kinase

pKd : 7.89

GSK690693

PRKACBTchem Kinase

pKd : 6.24

AT-13148

PRKACBTchem Kinase

pKd : 7.6

Protein-Protein Interactions (818)

Explore Interacting Targets

1 – 10 of 818

• See Interactions on String-DB

PRKAR2B

Tchem

Family:  Enzyme

Novelty:  0.00456972

p_int:  1

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

PRKAR1A

Tbio

Family:  Enzyme

Novelty:  0.00311432

p_int:  0.999999993

p_ni:  7e-9

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

GPR161

Tbio

Family:  GPCR

Novelty:  0.00235739

p_int:  0.999999242

p_ni:  7.58e-7

Score:  0.963

Data Source:  BioPlex,STRINGDB

Q9P0M2

Tbio

Family:  Enzyme

Novelty:  0.04114095

p_int:  0.99999896

p_ni:  0.000001018

p_wrong:  2.2e-8

Score:  0.606

Data Source:  BioPlex,STRINGDB

AKAP9

Tbio

Family:  Enzyme

Novelty:  0.0106532

p_int:  0.999998835

p_ni:  0.000001165

Score:  0.954

Data Source:  BioPlex,STRINGDB

AKAP11

Tbio

Family:  Enzyme

Novelty:  0.0685826

p_int:  0.999998035

p_ni:  0.000001965

Score:  0.706

Data Source:  BioPlex,STRINGDB

AKAP5

Tbio

Family:  Enzyme

Novelty:  0.00351101

p_int:  0.999997469

p_ni:  7.05e-7

p_wrong:  0.000001826

Score:  0.98

Data Source:  BioPlex,Reactome,STRINGDB

AKAP14

Tbio

Family:  Enzyme

Novelty:  0.50699923

p_int:  0.999980368

p_ni:  0.000019631

p_wrong:  1e-9

Score:  0.929

Data Source:  BioPlex,STRINGDB

PRKAR1B

Tbio

Family:  Enzyme

Novelty:  0.05355517

p_int:  0.999975872

p_ni:  0.000024121

p_wrong:  7e-9

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

PRKACG

Tchem

Family:  Kinase

Novelty:  0.11080061

p_int:  0.999958659

p_ni:  0.000041341

Score:  0.981

Data Source:  BioPlex,Reactome,STRINGDB

Nearest Tclin Targets (54)

Explore Nearest Tclin Targets

Upstream (6)

Downstream (48)

1 – 5 of 6

IGF1R

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  11

1: Endocrine resistance

2: Longevity regulating pathway

3: Oocyte meiosis

4: Longevity regulating pathway - multiple species

more:  7 more common pathways

ITGB1

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  6

1: Platelet activation

2: Dilated cardiomyopathy (DCM)

3: Tight junction

4: Proteoglycans in cancer

more:  2 more common pathways

KCNQ1

Tclin

Family:  Ion Channel

KEGG Distance:  1

Common Pathways:  4

1: Gastric acid secretion

2: Vibrio cholerae infection

3: Adrenergic signaling in cardiomyocytes

4: Cholinergic synapse

PGR

Tclin

Family:  Nuclear Receptor

KEGG Distance:  1

Common Pathways:  3

1: Oocyte meiosis

2: Estrogen signaling pathway

3: Progesterone-mediated oocyte maturation

AR

Tclin

Family:  Nuclear Receptor

KEGG Distance:  1

Common Pathways:  2

1: Oocyte meiosis

2: Pathways in cancer

Pathways (185)

Reactome (64)

KEGG (68)

PathwayCommons (36)

WikiPathways (17)

Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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5

1 – 5 of 64

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Aquaporin-mediated transport	55 targets	R-HSA-445717
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481

Name	Explore in Pharos	Explore in Source
Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Adaptive Immune System	894 targets	R-HSA-1280218
Aquaporin-mediated transport	55 targets	R-HSA-445717
Axon guidance	533 targets	R-HSA-422475
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (29)

Functions (6)

Components (9)

Processes (14)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
protein serine/threonine kinase activity	Inferred from Experiment (EXP)	Reactome
ATP binding	Inferred from Direct Assay (IDA)	UniProtKB
cAMP-dependent protein kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
magnesium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
ubiquitin protein ligase binding	Inferred from Direct Assay (IDA)	UniProtKB
protein kinase A regulatory subunit binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	1	1	1		11.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	1		11.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
ATP-binding
cAMP
Cell membrane
Complete proteome
Cytoplasm
Kinase
Lipoprotein
Membrane
Myristate

GWAS Trait Find Similar Targets

No Header	No Header
platelet count

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
nervous system phenotype

IDG Resources

Data Resources (1)

NanoBRET

NanoLuc®-fused PRKACB

• Institute:  UNC-CH
• Authors:  Julie Pickett
• PI:  Tim Willson
• Assay ID:  BAO_0010069
• Endpoint:  fold change
• Endpoint Detection:  fluorescence intensity
• Data: NanoBRET Assay Tracer Titration

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	protein kinase cAMP-activated catalytic subunit beta	VGNC:11804	469367
Macaque	protein kinase cAMP-activated catalytic subunit beta		709728
Mouse	protein kinase, cAMP dependent, catalytic, beta	MGI:97594	18749
Rat	protein kinase cAMP-activated catalytic subunit beta	RGD:1310574	293508
Dog	protein kinase cAMP-activated catalytic subunit beta	VGNC:44971	479975

Species	Name	OMA	EggNOG	Inparanoid
Chimp	protein kinase cAMP-activated catalytic subunit beta
Macaque	protein kinase cAMP-activated catalytic subunit beta
Mouse	protein kinase, cAMP dependent, catalytic, beta
Rat	protein kinase cAMP-activated catalytic subunit beta
Dog	protein kinase cAMP-activated catalytic subunit beta

Publication Statistics

PubMed Score 50.96

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PubTator Score 20.23

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Patents

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Related Publications

Text Mined References (58)

GeneRif Annotations (23)

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PMID	Year	Title