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Tchem
PRKACA
cAMP-dependent protein kinase catalytic subunit alpha

Protein Summary
Description
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308677
  • ENSP00000309591
  • ENSG00000072062
  • ENST00000589994
  • ENSP00000466651

Symbol
  • PKACA
  • PKACA
  • PPNAD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug
1
hub protein
1
pathway
1
interacting protein
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.84   (req: < 5)
Gene RIFs: 213   (req: <= 3)
Antibodies: 458   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.84   (req: >= 5)
Gene RIFs: 213   (req: > 3)
Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 59
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (980)
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.999651283
p_ni:  0.000348717
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
AKAP14
Tbio
Family:  Enzyme
Novelty:  0.50699923
p_int:  0.996585789
p_ni:  0.003414211
Score:  0.962
Data Source:  BioPlex,STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.996082593
p_ni:  0.003917407
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
p_int:  0.990792758
p_ni:  0.009207239
p_wrong:  3e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
GPR161
Tbio
Family:  GPCR
Novelty:  0.00235739
p_int:  0.977925455
p_ni:  0.022074545
Score:  0.982
Data Source:  BioPlex,STRINGDB
PRKAR2A
Tchem
Family:  Enzyme
Novelty:  0.06183318
Score:  0.997
Data Source:  Reactome,STRINGDB
PRKAR1B
Tbio
Family:  Enzyme
Novelty:  0.05355517
Score:  0.996
Data Source:  Reactome,STRINGDB
PKIA
Tbio
Family:  Enzyme
Novelty:  0.02581954
Score:  0.994
Data Source:  STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
Score:  0.976
Data Source:  STRINGDB
PDE4B
Tclin
Family:  Enzyme
Novelty:  0.00528932
Score:  0.965
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (54)
Explore Nearest Tclin Targets
1 – 5 of 6
ITGB1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
AR
Tclin
Family:  Nuclear Receptor
KEGG Distance:  1
Common Pathways:  2
Pathways (246)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 95
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Adaptive Immune System
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Aquaporin-mediated transport
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Activation of NMDA receptors and postsynaptic events
Adaptive Immune System
Anchoring of the basal body to the plasma membrane
Aquaporin-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (73)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
62.1
lymphocyte count
1
1
1
58.4
reticulocyte count
2
2
2
56.6
lymphocyte percentage of leukocytes
1
1
1
53.7
sex hormone-binding globulin measurement
2
1
2
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
62.1
lymphocyte count
1
58.4
reticulocyte count
2
56.6
lymphocyte percentage of leukocytes
1
53.7
sex hormone-binding globulin measurement
2
40.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase cAMP-activated catalytic subunit alpha
VGNC:12065
107966260
Mouse
MGI:97592
18747
Rat
RGD:3389
25636
Dog
protein kinase cAMP-activated catalytic subunit alpha
403556
Horse
protein kinase cAMP-activated catalytic subunit alpha
VGNC:49525
100064302
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase cAMP-activated catalytic subunit alpha
Mouse
Rat
Dog
protein kinase cAMP-activated catalytic subunit alpha
Horse
protein kinase cAMP-activated catalytic subunit alpha
Publication Statistics
PubMed Score 21.84
PubMed score by year
PubTator Score 79.05
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title