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Tchem
PRKAB1
5'-AMP-activated protein kinase subunit beta-1

Protein Summary
Description
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229328
  • ENSP00000229328
  • ENSG00000111725
  • ENST00000541640
  • ENSP00000441369

Symbol
  • AMPK
  • AMPK
  • HAMPKb
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
drug perturbation
0.99
interacting protein
0.99
transcription factor binding site profile
0.96
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.66   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 708   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.66   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 708   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (152)
PRKAG1
Tchem
Family:  Kinase
Novelty:  0.07735301
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRKAG2
Tchem
Family:  Enzyme
Novelty:  0.00741608
p_int:  1
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKAA2
Tchem
Family:  Kinase
Novelty:  0.01795523
p_int:  0.999999868
p_ni:  1.3e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRKAA1
Tclin
Family:  Kinase
Novelty:  0.01205826
p_int:  0.999999663
p_ni:  3.37e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRKAG3
Tbio
Family:  Enzyme
Novelty:  0.01865144
p_int:  0.999997046
p_ni:  0.000002936
p_wrong:  1.8e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
p_int:  0.999511883
p_ni:  0.000001124
p_wrong:  0.000486993
Score:  0.982
Data Source:  BioPlex,STRINGDB
DCLRE1C
Tbio
Novelty:  0.01064408
p_int:  0.999459195
p_ni:  0.0005408
p_wrong:  6e-9
Score:  0.747
Data Source:  BioPlex,STRINGDB
STIM2
Tbio
Novelty:  0.00446493
p_int:  0.998798
p_ni:  0.001201904
p_wrong:  9.6e-8
Score:  0.817
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.998559264
p_ni:  0.001440733
p_wrong:  3e-9
Data Source:  BioPlex
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.998379389
p_ni:  0.001620611
Score:  0.177
Data Source:  BioPlex,STRINGDB
Pathways (67)
Activation of AMPK downstream of NMDARs (R-HSA-9619483)

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Find Similar Targets
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AMPK downstream of NMDARs
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors and postsynaptic events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Autophagy
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
84.7
basophil count
2
2
2
78.7
myeloid white cell count
1
1
1
71.9
serum gamma-glutamyl transferase measurement
1
1
1
68
leukocyte count
1
1
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
84.7
basophil count
2
78.7
myeloid white cell count
1
71.9
serum gamma-glutamyl transferase measurement
1
68
leukocyte count
1
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase AMP-activated non-catalytic subunit beta 1
VGNC:8503
452297
Macaque
protein kinase AMP-activated non-catalytic subunit beta 1
695737
Mouse
MGI:1336167
19079
Rat
RGD:71057
83803
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase AMP-activated non-catalytic subunit beta 1
Macaque
protein kinase AMP-activated non-catalytic subunit beta 1
Mouse
Rat
Publication Statistics
PubMed Score 59.66
PubMed score by year
PubTator Score 56.87
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title