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Tchem
PRKAA2
5'-AMP-activated protein kinase catalytic subunit alpha-2

Protein Summary
Description
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371244
  • ENSP00000360290
  • ENSG00000162409

Symbol
  • AMPK
  • AMPK2
  • AMPK
  • AMPK2
  • PRKAA
  • AMPKa2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical bioactivity profile
1
molecular function
0.99
protein domain
0.92
biological term
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.97   (req: < 5)
Gene RIFs: 94   (req: <= 3)
Antibodies: 754   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.97   (req: >= 5)
Gene RIFs: 94   (req: > 3)
Antibodies: 754   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (21)
staurosporine
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JNJ-28312141
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US9428501, 58
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US9428501, 57
Rendered image for US9428501, 57
US9428501, 35
Rendered image for US9428501, 35
US9428501, 18
Rendered image for US9428501, 18
US9428501, 49
Rendered image for US9428501, 49
US9428501, 69
Rendered image for US9428501, 69
US9428501, 50
Rendered image for US9428501, 50
US9428501, 44
Rendered image for US9428501, 44
Protein-Protein Interactions (162)
PRKAB1
Tchem
Family:  Kinase
Novelty:  0.01610606
p_int:  0.999999868
p_ni:  1.3e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRKAG1
Tchem
Family:  Kinase
Novelty:  0.07735301
p_int:  0.999999859
p_ni:  1.41e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
p_int:  0.999999213
p_ni:  7.87e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRKAG2
Tchem
Family:  Enzyme
Novelty:  0.00741608
p_int:  0.999997601
p_ni:  0.000002399
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKAG3
Tbio
Family:  Enzyme
Novelty:  0.01865144
p_int:  0.999921676
p_ni:  0.000078324
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
DCLRE1C
Tbio
Novelty:  0.01064408
p_int:  0.999243183
p_ni:  0.000756817
p_wrong:  1e-9
Score:  0.833
Data Source:  BioPlex,STRINGDB
LAMTOR1
Tbio
Novelty:  0.04952213
p_int:  0.997075509
p_ni:  0.002924491
Score:  0.901
Data Source:  BioPlex,STRINGDB
STIM2
Tbio
Novelty:  0.00446493
p_int:  0.99574961
p_ni:  0.00425039
Score:  0.874
Data Source:  BioPlex,STRINGDB
SRSF2
Tbio
Novelty:  0.00207072
p_int:  0.932733077
p_ni:  0.067266834
p_wrong:  8.8e-8
Data Source:  BioPlex
CTNNA3
Tbio
Novelty:  0.01472452
p_int:  0.858207701
p_ni:  0.141792299
Score:  0.208
Data Source:  BioPlex,STRINGDB
Pathways (84)
AMPK inhibits chREBP transcriptional activation activity (R-HSA-163680)

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Find Similar Targets
Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMPK inhibits chREBP transcriptional activation activity
Reactome
Activation of AMPK downstream of NMDARs
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Autophagy
Name
Explore in Pharos
Explore in Source
AMPK inhibits chREBP transcriptional activation activity
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors and postsynaptic events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Autophagy
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (56)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
1.1
83.2
testosterone measurement
2
2
2
54.3
educational attainment
1
1
1
38.8
Calcium channel blocker use measurement
2
1
2
19
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
83.2
testosterone measurement
2
54.3
educational attainment
1
38.8
Calcium channel blocker use measurement
2
19
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase AMP-activated catalytic subunit alpha 2
VGNC:11800
741802
Macaque
protein kinase AMP-activated catalytic subunit alpha 2
717703
Mouse
MGI:1336173
108079
Rat
RGD:620893
78975
Dog
protein kinase AMP-activated catalytic subunit alpha 2
VGNC:53435
489571
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase AMP-activated catalytic subunit alpha 2
Macaque
protein kinase AMP-activated catalytic subunit alpha 2
Mouse
Rat
Dog
protein kinase AMP-activated catalytic subunit alpha 2
Publication Statistics
PubMed Score 56.97
PubMed score by year
PubTator Score 921.28
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title