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Tclin
PRKAA1
5'-AMP-activated protein kinase catalytic subunit alpha-1

Protein Summary
Description
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354209
  • ENSP00000346148
  • ENSG00000132356
  • ENST00000397128
  • ENSP00000380317

Symbol
  • AMPK1
  • AMPK
  • AMPKa1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical bioactivity profile
1
drug perturbation
1
interacting protein
1
molecular function
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.64   (req: < 5)
Gene RIFs: 326   (req: <= 3)
Antibodies: 1299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.64   (req: >= 5)
Gene RIFs: 326   (req: > 3)
Antibodies: 1299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 71
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2