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Tbio
PRIMA1
Proline-rich membrane anchor 1

Protein Summary
Description
Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity). The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316227
  • ENSP00000320948
  • ENSG00000175785
  • ENST00000393140
  • ENSP00000376848
  • ENST00000393143
  • ENSP00000376851
  • ENST00000477603
  • ENSP00000434370
  • ENST00000611347
  • ENSP00000479082
  • ENSG00000274089
  • ENST00000617019
  • ENSP00000479855
  • ENST00000627063
  • ENSP00000486875
  • ENST00000629961
  • ENSP00000486953

Symbol
  • PRIMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
cell type or tissue
0.56
PubMedID
0.56
tissue
0.51
transcription factor binding site profile
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.79   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.79   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
ACHE
Tclin
Family:  Enzyme
Novelty:  0.00026957
Score:  0.797
Data Source:  STRINGDB
COLQ
Tbio
Family:  Enzyme
Novelty:  0.01414634
Score:  0.734
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.669
Data Source:  STRINGDB
FAM181A
Tdark
Novelty:  0.6096481
Score:  0.66
Data Source:  STRINGDB
MDM2
Tchem
Family:  Enzyme
Novelty:  0.00028385
Score:  0.647
Data Source:  STRINGDB
TTC7B
Tbio
Novelty:  0.22257455
Score:  0.595
Data Source:  STRINGDB
CABP2
Tbio
Novelty:  0.08451877
Score:  0.566
Data Source:  STRINGDB
DDX24
Tbio
Family:  Enzyme
Novelty:  0.17803446
Score:  0.559
Data Source:  STRINGDB
SIPA1L1
Tdark
Novelty:  0.13134052
Score:  0.557
Data Source:  STRINGDB
PMAIP1
Tbio
Novelty:  0.00198406
Score:  0.557
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
64.3
body mass index
2
2
2
64.3
body fat percentage
1
1
1
24.5
body fat percentage
1
1
1
24.5
sleep duration
1
1
1
15.8
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
64.3
body mass index
2
64.3
body fat percentage
1
24.5
body fat percentage
1
24.5
sleep duration
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proline rich membrane anchor 1
104002150
Mouse
MGI:1926097
170952
Rat
RGD:1583978
690195
Dog
proline rich membrane anchor 1
VGNC:51672
610948
Horse
proline rich membrane anchor 1
100064321
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proline rich membrane anchor 1
Mouse
Rat
Dog
proline rich membrane anchor 1
Horse
proline rich membrane anchor 1
Publication Statistics
PubMed Score 65.79
PubMed score by year
PubTator Score 216.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title