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Tbio
PRIM2
DNA primase large subunit

Protein Summary
Description
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274891
  • ENSP00000485304
  • ENSG00000146143
  • ENST00000370687
  • ENSP00000483201
  • ENST00000615550
  • ENSP00000484105

Symbol
  • PRIM2A
  • p58
  • PRIM2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
virus perturbation
0.88
histone modification site profile
0.85
disease perturbation
0.79
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.75   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.75   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (198)
PRIM1
Tbio
Family:  Enzyme
Novelty:  0.0530384
p_int:  0.999999684
p_ni:  3.16e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
BTF3
Tbio
Novelty:  0.01198537
p_int:  0.999705484
p_ni:  0.000294516
Data Source:  BioPlex
BTF3L4
Tdark
Novelty:  0.61724061
p_int:  0.999509703
p_ni:  0.000490297
Data Source:  BioPlex
NLGN4Y
Tbio
Family:  Enzyme
p_int:  0.998068671
p_ni:  0.001931329
Data Source:  BioPlex
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
p_int:  0.994660253
p_ni:  0.005339747
p_wrong:  1e-9
Score:  0.542
Data Source:  BioPlex,STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.983294945
p_ni:  0.016705055
Data Source:  BioPlex
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.929085208
p_ni:  0.070914792
Score:  0.152
Data Source:  BioPlex,STRINGDB
DCAF10
Tdark
Novelty:  2.6713128
p_int:  0.881499448
p_ni:  0.118500552
Score:  0.649
Data Source:  BioPlex,STRINGDB
PM20D2
Tdark
Family:  Enzyme
Novelty:  0.63491472
p_int:  0.879065905
p_ni:  0.120789866
p_wrong:  0.00014423
Score:  0.239
Data Source:  BioPlex,STRINGDB
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.836065118
p_ni:  0.163934881
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
Pathways (28)
Activation of the pre-replicative complex (R-HSA-68962)

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Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Replication
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Replication
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
4
89.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
89.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DNA primase subunit 2
712921
Mouse
MGI:97758
19076
Rat
RGD:631433
301323
Dog
DNA primase subunit 2
VGNC:49102
474950
Horse
DNA primase subunit 2
VGNC:50492
100056923
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DNA primase subunit 2
Mouse
Rat
Dog
DNA primase subunit 2
Horse
DNA primase subunit 2
Publication Statistics
PubMed Score 25.75
PubMed score by year
PubTator Score 16.15
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title