You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRICKLE3
Prickle planar cell polarity protein 3

Protein Summary
Description
Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000599218
  • ENSP00000470248
  • ENSG00000012211

Symbol
  • LMO6
  • Pk3
  • LMO6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.67
cell type or tissue
0.65
tissue sample
0.62
small molecule perturbation
0.59
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
METTL18
Tdark
Family:  Enzyme
Novelty:  0.3377377
p_int:  0.999998852
p_ni:  0.000001147
p_wrong:  1e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
PLCD3
Tbio
Family:  Enzyme
Novelty:  0.04749421
p_int:  0.999986846
p_ni:  0.000013154
Data Source:  BioPlex
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.999969154
p_ni:  0.000030334
p_wrong:  5.12e-7
Data Source:  BioPlex
PRDM10
Tbio
Family:  TF; Epigenetic
Novelty:  0.03463517
p_int:  0.999961186
p_ni:  0.000038812
p_wrong:  3e-9
Data Source:  BioPlex
PIP4K2C
Tchem
Family:  Kinase
Novelty:  0.11466436
p_int:  0.999678241
p_ni:  0.000321759
Data Source:  BioPlex
EPB41L5
Tbio
Novelty:  0.0391959
p_int:  0.997767949
p_ni:  0.002232051
Data Source:  BioPlex
SIAH2
Tbio
Family:  Enzyme
Novelty:  0.01461174
p_int:  0.996521617
p_ni:  0.000008089
p_wrong:  0.003470294
Score:  0.181
Data Source:  BioPlex,STRINGDB
TUBGCP4
Tbio
Novelty:  0.04549455
p_int:  0.995950546
p_ni:  0.004049352
p_wrong:  1.02e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.995400887
p_ni:  0.004599113
Data Source:  BioPlex
HSP90AA4P
Tdark
p_int:  0.994405512
p_ni:  0.005594451
p_wrong:  3.7e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
46.1
childhood onset asthma
1
1
0
1
38.2
mean platelet volume
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
46.1
childhood onset asthma
0
1
38.2
mean platelet volume
1
13.5
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
prickle planar cell polarity protein 3
715644
Mouse
MGI:1859635
54630
Rat
RGD:1359685
317380
Dog
prickle planar cell polarity protein 3
VGNC:44967
491874
Horse
prickle planar cell polarity protein 3
VGNC:21834
100062774
Species
Name
OMA
EggNOG
Inparanoid
Macaque
prickle planar cell polarity protein 3
Mouse
Rat
Dog
prickle planar cell polarity protein 3
Horse
prickle planar cell polarity protein 3
Publication Statistics
PubMed Score 5.75
PubMed score by year
PubTator Score 0.67
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title