Tbio PRICKLE3 Prickle planar cell polarity protein 3

Protein Summary

Description

Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43900
• B7Z8F2
• O76007
• Q53XR5

Gene Name

• PRICKLE3

Ensembl ID

• ENST00000599218
• ENSP00000470248
• ENSG00000012211

Symbol

• LMO6
• Pk3
• LMO6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.67
cell type or tissue	0.65
tissue sample	0.62
small molecule perturbation	0.59
cell line	0.55

Protein Classes

PANTHER Classes

Protein / Structural Protein / Prickle Planar Cell Polarity Protein 3

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Prickle Planar Cell Polarity Protein 3

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Prickle Planar Cell Polarity Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.03   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.03   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0