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Tbio
PRICKLE2
Prickle-like protein 2

Protein Summary
Description
This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000564377
  • ENSP00000455004
  • ENSG00000163637
  • ENST00000638394
  • ENSP00000492363

Symbol
  • EPM5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
virus perturbation
0.68
tissue sample
0.66
cell type or tissue
0.62
transcription factor
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.03   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.03   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
VANGL1
Tbio
Novelty:  0.00968008
Score:  0.983
Data Source:  STRINGDB
VANGL2
Tbio
Novelty:  0.00529796
Score:  0.982
Data Source:  STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.903
Data Source:  STRINGDB
DVL3
Tbio
Novelty:  0.01606014
Score:  0.903
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.894
Data Source:  STRINGDB
CELSR1
Tbio
Family:  GPCR
Novelty:  0.02076192
Score:  0.757
Data Source:  STRINGDB
CELSR3
Tbio
Family:  GPCR
Novelty:  0.02705624
Score:  0.739
Data Source:  STRINGDB
CELSR2
Tbio
Family:  GPCR
Novelty:  0.02657319
Score:  0.732
Data Source:  STRINGDB
ANKRD6
Tbio
Novelty:  0.06681094
Score:  0.708
Data Source:  STRINGDB
WNT11
Tbio
Novelty:  0.0045754
Score:  0.705
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
4
3
2
1.1
94.2
self reported educational attainment
2
2
2
75.1
educational attainment
1
2
2
74
Drugs used in diabetes use measurement
2
2
2
67.5
cortical thickness
1
1
0
7.9
54
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
1.1
94.2
self reported educational attainment
2
75.1
educational attainment
2
74
Drugs used in diabetes use measurement
2
67.5
cortical thickness
0
7.9
54
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prickle planar cell polarity protein 2
VGNC:2523
465217
Macaque
prickle planar cell polarity protein 2
701254
Mouse
MGI:1925144
243548
Rat
RGD:1306723
312563
Dog
prickle planar cell polarity protein 2
VGNC:44966
484699
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prickle planar cell polarity protein 2
Macaque
prickle planar cell polarity protein 2
Mouse
Rat
Dog
prickle planar cell polarity protein 2
Publication Statistics
PubMed Score 25.03
PubMed score by year
PubTator Score 9.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title