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Tbio
PRG3
Proteoglycan 3

Protein Summary
Description
Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287143
  • ENSP00000287143
  • ENSG00000156575

Symbol
  • MBPH
  • MBP2
  • MBPH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
biological process
0.79
protein domain
0.73
tissue
0.48
cell line
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.56   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.56   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
p_int:  0.999865055
p_ni:  0.000134945
Data Source:  BioPlex
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.999463176
p_ni:  0.000536824
Data Source:  BioPlex
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
p_int:  0.998028515
p_ni:  0.001971485
Data Source:  BioPlex
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.996973131
p_ni:  0.003026869
Score:  0.908
Data Source:  BioPlex,STRINGDB
GID4
Tbio
Novelty:  0.05252674
p_int:  0.996454882
p_ni:  0.003545118
Data Source:  BioPlex
MKLN1
Tbio
Novelty:  0.05014385
p_int:  0.995699348
p_ni:  0.004300652
Data Source:  BioPlex
EOGT
Tbio
Family:  Enzyme
Novelty:  0.08290891
p_int:  0.994880865
p_ni:  0.005104407
p_wrong:  0.000014728
Data Source:  BioPlex
LDLR
Tchem
Novelty:  0.06585434
p_int:  0.99389987
p_ni:  0.005976861
p_wrong:  0.000123269
Data Source:  BioPlex
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.992929862
p_ni:  0.007070138
Score:  0.802
Data Source:  BioPlex,STRINGDB
RANBP10
Tbio
Novelty:  0.10818049
p_int:  0.986741106
p_ni:  0.013258894
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pappalysin‐1 measurement
1
2
2
88.9
eosinophil count
5
4
6
83.3
eosinophil percentage of leukocytes
2
3
3
71.5
1
1
0
65.3
67.5
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pappalysin‐1 measurement
2
88.9
eosinophil count
6
83.3
eosinophil percentage of leukocytes
3
71.5
0
65.3
67.5
1
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteoglycan 3, pro eosinophil major basic protein 2
VGNC:1032
466586
Macaque
proteoglycan 3, pro eosinophil major basic protein 2
706381
Mouse
MGI:1858200
53856
Rat
RGD:1309904
295706
Dog
proteoglycan 3, pro eosinophil major basic protein 2
VGNC:52036
483495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteoglycan 3, pro eosinophil major basic protein 2
Macaque
proteoglycan 3, pro eosinophil major basic protein 2
Mouse
Rat
Dog
proteoglycan 3, pro eosinophil major basic protein 2
Publication Statistics
PubMed Score 21.56
PubMed score by year
PubTator Score 13.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title