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Tbio
PRG2
Bone marrow proteoglycan

Protein Summary
Description
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311862
  • ENSP00000312134
  • ENSG00000186652
  • ENST00000525955
  • ENSP00000433016
  • ENST00000533605
  • ENSP00000433231

Symbol
  • MBP
  • MBP
  • BMPG
  • MBP1
  • proMBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.75
protein domain
0.73
cell type or tissue
0.65
kinase perturbation
0.6
biological term
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.33   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.33   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999984736
p_ni:  0.000015264
Data Source:  BioPlex
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999707903
p_ni:  0.000292097
Data Source:  BioPlex
FOXF2
Tbio
Family:  TF
Novelty:  0.02032168
p_int:  0.999640049
p_ni:  0.000318575
p_wrong:  0.000041375
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.999344366
p_ni:  0.000655341
p_wrong:  2.94e-7
Score:  0.155
Data Source:  BioPlex,STRINGDB
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
p_int:  0.999223775
p_ni:  0.000776208
p_wrong:  1.7e-8
Data Source:  BioPlex
SIPA1L2
Tbio
Novelty:  0.2002618
p_int:  0.998505014
p_ni:  0.001494986
Data Source:  BioPlex
DVL2
Tbio
Novelty:  0.00833084
p_int:  0.996599418
p_ni:  0.003400559
p_wrong:  2.3e-8
Data Source:  BioPlex
TOR3A
Tbio
Novelty:  0.11588309
p_int:  0.996471552
p_ni:  0.003528448
Data Source:  BioPlex
N4BP2L2
Tbio
Novelty:  0.24527466
p_int:  0.992815306
p_ni:  0.007184693
Data Source:  BioPlex
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.992787928
p_ni:  0.007212072
Score:  0.199
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
4
91.9
pappalysin‐1 measurement
1
2
2
89.6
eosinophil percentage of leukocytes
2
3
3
80.7
mean corpuscular volume
1
1
1
53.3
1
1
1
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
91.9
pappalysin‐1 measurement
2
89.6
eosinophil percentage of leukocytes
3
80.7
mean corpuscular volume
1
53.3
1
51.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteoglycan 2, pro eosinophil major basic protein
100612951
Mouse
MGI:103294
19074
Rat
RGD:69336
58826
Horse
proteoglycan 3-like
100066745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteoglycan 2, pro eosinophil major basic protein
Mouse
Rat
Horse
proteoglycan 3-like
Publication Statistics
PubMed Score 166.33
PubMed score by year
PubTator Score 171.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title