Protein Summary
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoprol ...more
- ENST00000373209
- ENSP00000362305
- ENSG00000180644
- ENST00000441259
- ENSP00000398568
- PFP
- P1
- PFP
- HPLH2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.93 | ||
biological term | 0.92 | ||
PubMedID | 0.74 | ||
tissue sample | 0.68 | ||
cell type or tissue | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3321.1 (req: < 5)
Gene RIFs: 155 (req: <= 3)
Antibodies: 539 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3321.1 (req: >= 5)
Gene RIFs: 155 (req: > 3)
Antibodies: 539 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 28
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (28)
Protein-Protein Interactions (328)
Nearest Tclin Targets
Pathways (31)
KEGG (7)
PathwayCommons (5)
WikiPathways (19)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Allograft rejection | ||||
KEGG | Graft-versus-host disease | ||||
KEGG | Viral myocarditis | ||||
KEGG | Type I diabetes mellitus | ||||
KEGG | Autoimmune thyroid disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Allograft rejection | ||||
Graft-versus-host disease | ||||
Viral myocarditis | ||||
Type I diabetes mellitus | ||||
Autoimmune thyroid disease | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (3)
Components (7)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 6 | 11 | 95.9 | |||||
lymphocyte count | 1 | 1 | 1 | 78.4 | |||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 74.8 | |||||
body fat distribution | 2 | 1 | 4 | 61 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 12.2 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 11 | 95.9 | |||||
lymphocyte count | 1 | 78.4 | |||||
lymphocyte percentage of leukocytes | 2 | 74.8 | |||||
body fat distribution | 4 | 61 | |||||
neutrophil percentage of leukocytes | 1 | 12.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:97551 | 18646 | ||||||
Rat | RGD:708463 | 50669 | ||||||
Dog | perforin 1 | VGNC:44964 | 489030 | |||||
Horse | perforin 1 | VGNC:21831 | 100072744 | |||||
Cow | perforin 1 | VGNC:33313 | 369025 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | perforin 1 | |||||
Horse | perforin 1 | |||||
Cow | perforin 1 | |||||
Publication Statistics
PubMed Score 3321.10
PubMed score by year
PubTator Score 327.91
PubTator score by year
Related Publications
Text Mined References (192)
GeneRif Annotations (155)
Items per page:
0 of 0
PMID | Year | Title |
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