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Tchem
PREPL
Prolyl endopeptidase-like

Protein Summary
Description
Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. May play a role in the regulation of synaptic vesiscle exocytosis (PubMed:24610330). The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260648
  • ENSP00000260648
  • ENSG00000138078
  • ENST00000378511
  • ENSP00000367772
  • ENST00000378520
  • ENSP00000367781
  • ENST00000409272
  • ENSP00000386909
  • ENST00000409411
  • ENSP00000387095
  • ENST00000409936
  • ENSP00000386543
  • ENST00000409957
  • ENSP00000387241
  • ENST00000410081
  • ENSP00000386509
  • ENST00000425263
  • ENSP00000391456
  • ENST00000426481
  • ENSP00000409480
  • ENST00000541738
  • ENSP00000439626

Symbol
  • KIAA0436
  • CMS22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.97
disease perturbation
0.9
histone modification site profile
0.87
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.21   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.21   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0