You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PREP
Prolyl endopeptidase

Protein Summary
Description
Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369110
  • ENSP00000358106
  • ENSG00000085377

Symbol
  • PEP
  • PE
  • PEP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
virus perturbation
0.88
transcription factor binding site profile
0.83
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 699.31   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 699.31   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 253
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (253)
talabostat
Rendered image for talabostat
CHEMBL210805
Rendered image for CHEMBL210805
Boronic acid derivative
Rendered image for Boronic acid derivative
CHEMBL209940
Rendered image for CHEMBL209940
CHEMBL380090
Rendered image for CHEMBL380090
CHEMBL436744
Rendered image for CHEMBL436744
CHEMBL481669
Rendered image for CHEMBL481669
CHEMBL377296
Rendered image for CHEMBL377296
CHEMBL378867
Rendered image for CHEMBL378867
Protein-Protein Interactions (77)
MTG2
Tbio
Family:  Enzyme
Novelty:  0.06104792
p_int:  0.999653288
p_ni:  0.000346712
Score:  0.189
Data Source:  BioPlex,STRINGDB
NSMAF
Tbio
Novelty:  0.08595515
p_int:  0.998699401
p_ni:  0.001300599
Score:  0.267
Data Source:  BioPlex,STRINGDB
SGO2
Tbio
Novelty:  0.05544423
p_int:  0.985702902
p_ni:  0.014297098
Score:  0.226
Data Source:  BioPlex,STRINGDB
RHPN1
Tbio
Novelty:  0.05722992
p_int:  0.955851957
p_ni:  0.044148043
Score:  0.188
Data Source:  BioPlex,STRINGDB
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.903182992
p_ni:  0.096817008
Score:  0.189
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.795612968
p_ni:  0.204377637
p_wrong:  0.000009395
Data Source:  BioPlex
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.869
Data Source:  STRINGDB
DPP8
Tchem
Family:  Enzyme
Novelty:  0.00678793
Score:  0.859
Data Source:  STRINGDB
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
Score:  0.859
Data Source:  STRINGDB
DPP4
Tclin
Family:  Enzyme
Novelty:  0.00017047
Score:  0.771
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
2
2
85.3
electrocardiography
1
1
16
40.1
T wave morphology measurement
1
1
1
31.4
balding measurement
1
1
1
30.2
QT interval
1
1
1
27.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
85.3
electrocardiography
16
40.1
T wave morphology measurement
1
31.4
balding measurement
1
30.2
QT interval
1
27.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prolyl endopeptidase
VGNC:11186
462903
Macaque
prolyl endopeptidase
696633
Mouse
MGI:1270863
19072
Rat
RGD:620841
83471
Dog
prolyl endopeptidase
VGNC:44960
481945
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prolyl endopeptidase
Macaque
prolyl endopeptidase
Mouse
Rat
Dog
prolyl endopeptidase
Publication Statistics
PubMed Score 699.31
PubMed score by year
PubTator Score 614.83
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title