Tdark PRELID2 PRELI domain-containing protein 2

Protein Summary

Uniprot Accession IDs

• Q8N945
• G5EA01
• Q96EQ3

Gene Name

• PRELID2

Ensembl ID

• ENST00000334744
• ENSP00000335675
• ENSG00000186314
• ENST00000394450
• ENSP00000377965
• ENST00000505416
• ENSP00000424730

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.85
kinase perturbation	0.76
microRNA	0.67
tissue sample	0.65
transcription factor perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.68   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 61   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.68   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (41)

Explore Interacting Targets

1 – 10 of 41

• See Interactions on String-DB

EXPH5

Tbio

Novelty:  0.07504682

p_int:  0.999942622

p_ni:  0.000046737

p_wrong:  0.000010641

Data Source:  BioPlex

NCOA4

Tbio

Novelty:  0.00487453

p_int:  0.999404899

p_ni:  0.000204141

p_wrong:  0.00039096

Data Source:  BioPlex

BUB1

Tchem

Family:  Kinase

Novelty:  0.00327514

p_int:  0.998917312

p_ni:  0.001058822

p_wrong:  0.000023866

Data Source:  BioPlex

ALMS1

Tbio

Novelty:  0.00694228

p_int:  0.998084015

p_ni:  0.001915985

Data Source:  BioPlex

KNL1

Tbio

Novelty:  0.01084826

p_int:  0.991866133

p_ni:  0.008133867

Data Source:  BioPlex

FAM83D

Tbio

Novelty:  0.07381559

p_int:  0.962555717

p_ni:  0.037431005

p_wrong:  0.000013278

Data Source:  BioPlex

KIF11

Tchem

Novelty:  0.00170673

p_int:  0.950040287

p_ni:  0.049959713

Data Source:  BioPlex

MLF1

Tbio

Novelty:  0.0239522

p_int:  0.941317898

p_ni:  0.058682035

p_wrong:  6.7e-8

Data Source:  BioPlex

TP73

Tbio

Family:  TF

Novelty:  0.00667737

p_int:  0.930118207

p_ni:  0.069881793

Data Source:  BioPlex

CDK5RAP2

Tbio

Novelty:  0.00956263

p_int:  0.922178716

p_ni:  0.077820425

p_wrong:  8.58e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

Find Similar Targets

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GO Term	Evidence	Assigned by
phosphatidic acid transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
smoking status measurement	EFO_0006527	1	1	1		17.8
vitamin B12 measurement	EFO_0004620	1	1	0	43.9	15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
smoking status measurement	EFO_0006527	1		17.8
vitamin B12 measurement	EFO_0004620	0	43.9	15.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
smoking status measurement
vitamin B12 measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	PRELI domain containing 2	VGNC:4136	739950
Macaque	PRELI domain containing 2		706848
Mouse	PRELI domain containing 2	MGI:1924869	77619
Rat	PRELI domain containing 2	RGD:1584707	681037
Dog	PRELI domain containing 2	VGNC:44956	607778

Species	Name	OMA	EggNOG	Inparanoid
Chimp	PRELI domain containing 2
Macaque	PRELI domain containing 2
Mouse	PRELI domain containing 2
Rat	PRELI domain containing 2
Dog	PRELI domain containing 2

Publication Statistics

PubMed Score 2.68

PubMed score by year

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PubTator Score 0.20

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title