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Tbio
PREB
Prolactin regulatory element-binding protein

Protein Summary
Description
Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260643
  • ENSP00000260643
  • ENSG00000138073

Symbol
  • SEC12
  • SEC12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
kinase perturbation
0.88
cell type or tissue
0.65
tissue sample
0.65
cellular component
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.2   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.2   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
ICOSLG
Tbio
Novelty:  0.00693966
p_int:  0.839585789
p_ni:  0.160414211
Data Source:  BioPlex
ANO6
Tbio
Family:  IC
Novelty:  0.01288434
p_int:  0.808006725
p_ni:  0.191993275
Score:  0.187
Data Source:  BioPlex,STRINGDB
OCLN
Tbio
Novelty:  0.00047671
p_int:  0.772340427
p_ni:  0.227659573
Score:  0.187
Data Source:  BioPlex,STRINGDB
SAR1B
Tbio
Family:  Enzyme
Novelty:  0.02260817
Score:  0.988
Data Source:  Reactome,STRINGDB
SEC24B
Tbio
Novelty:  0.01031644
Score:  0.987
Data Source:  STRINGDB
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.984
Data Source:  Reactome,STRINGDB
CTAGE5
Tbio
Novelty:  0.04516631
Score:  0.983
Data Source:  STRINGDB
SEC24A
Tbio
Novelty:  0.07724534
Score:  0.983
Data Source:  STRINGDB
SAR1A
Tbio
Family:  Enzyme
Novelty:  0.0335242
Score:  0.976
Data Source:  STRINGDB
SEC24C
Tbio
Novelty:  0.05842956
Score:  0.971
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Reactome
IRE1alpha activates chaperones
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
IRE1alpha activates chaperones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
10
11
96.3
IGF-1 measurement
1
2
2
60.9
C-reactive protein measurement
2
2
2
58.3
total cholesterol measurement
1
1
1
56.2
sleep duration
2
2
2
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
11
96.3
IGF-1 measurement
2
60.9
C-reactive protein measurement
2
58.3
total cholesterol measurement
1
56.2
sleep duration
2
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prolactin regulatory element binding
VGNC:341
459094
Macaque
prolactin regulatory element binding
700408
Mouse
MGI:1355326
50907
Rat
RGD:61929
58842
Dog
prolactin regulatory element binding
VGNC:44954
483007
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prolactin regulatory element binding
Macaque
prolactin regulatory element binding
Mouse
Rat
Dog
prolactin regulatory element binding
Publication Statistics
PubMed Score 169.20
PubMed score by year
PubTator Score 175.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title