Tbio PRDX6 Peroxiredoxin-6

Protein Summary

Description

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30041
• A8JZY7
• P32077
• Q5TAH4
• Q5ZEZ8

Gene Name

• PRDX6

Ensembl ID

• ENST00000340385
• ENSP00000342026
• ENSG00000117592

Symbol

• AOP2
• KIAA0106
• PRX
• p29
• AOP2
• 1-Cys
• NSGPx
• aiPLA2
• HEL-S-128m

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
interacting protein	0.99
kinase perturbation	0.96
protein complex	0.96
transcription factor binding site profile	0.91

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Peroxidase / Peroxiredoxin-6

DTO Classes

Protein / Enzyme / Oxidoreductase / Peroxidase / Peroxiredoxin-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 640.33   (req: < 5)

Gene RIFs: 107   (req: <= 3)

Antibodies: 550   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 640.33   (req: >= 5)

Gene RIFs: 107   (req: > 3)

Antibodies: 550   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0