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Tbio
PRDX4
Peroxiredoxin-4

Protein Summary
Description
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379341
  • ENSP00000368646
  • ENSG00000123131

Symbol
  • PRX-4
  • AOE372
  • AOE37-2
  • HEL-S-97n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
virus perturbation
0.94
transcription factor perturbation
0.84
histone modification site profile
0.83
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.13   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.13   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
TXNDC5
Tbio
Novelty:  0.02369481
Score:  0.97
Data Source:  STRINGDB
ERP44
Tbio
Novelty:  0.02352693
Score:  0.958
Data Source:  STRINGDB
PDIA6
Tchem
Family:  Enzyme
Novelty:  0.01692178
Score:  0.936
Data Source:  STRINGDB
PRDX5
Tbio
Novelty:  0.00369421
Score:  0.874
Data Source:  STRINGDB
TXN
Tchem
Novelty:  0.00048949
Score:  0.865
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.827
Data Source:  STRINGDB
APOO
Tbio
Novelty:  0.04964756
Score:  0.824
Data Source:  STRINGDB
P4HB
Tchem
Family:  Enzyme
Novelty:  0.00107905
Score:  0.819
Data Source:  STRINGDB
TXNRD1
Tclin
Family:  Enzyme
Novelty:  0.00299018
Score:  0.805
Data Source:  STRINGDB
GLUL
Tchem
Family:  Enzyme
Novelty:  0.00086054
Score:  0.793
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (51)
Immune System (R-HSA-168256)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
peroxiredoxin 4
697635
Mouse
MGI:1859815
53381
Rat
RGD:620043
85274
Dog
peroxiredoxin 4
VGNC:44952
100856588
Horse
peroxiredoxin 4
VGNC:21820
100059985
Species
Name
OMA
EggNOG
Inparanoid
Macaque
peroxiredoxin 4
Mouse
Rat
Dog
peroxiredoxin 4
Horse
peroxiredoxin 4
Publication Statistics
PubMed Score 165.13
PubMed score by year
PubTator Score 90.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title