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Tbio
PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

Protein Summary
Description
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298510
  • ENSP00000298510
  • ENSG00000165672

Symbol
  • AOP1
  • AOP1
  • MER5
  • AOP-1
  • SP-22
  • HBC189
  • PRO1748
  • prx-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
kinase perturbation
0.93
molecular function
0.91
biological process
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.01   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.01   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (168)
OPA1
Tchem
Novelty:  0.0031868
p_int:  0.998093556
p_ni:  0.001906445
Score:  0.628
Data Source:  BioPlex,STRINGDB
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.985376613
p_ni:  0.014623387
Score:  0.224
Data Source:  BioPlex,STRINGDB
ZMYM6
Tdark
Novelty:  0.4933879
p_int:  0.966655173
p_ni:  0.033344678
p_wrong:  1.49e-7
Data Source:  BioPlex
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.903095837
p_ni:  0.071215954
p_wrong:  0.02568821
Score:  0.707
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.894601409
p_ni:  0.103375406
p_wrong:  0.002023185
Data Source:  BioPlex
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.884711298
p_ni:  0.115280912
p_wrong:  0.00000779
Score:  0.719
Data Source:  BioPlex,STRINGDB
PRDX1
Tchem
Novelty:  0.00207935
p_int:  0.79152401
p_ni:  0.20847599
Score:  0.885
Data Source:  BioPlex,STRINGDB
TXN2
Tbio
Novelty:  0.0059799
Score:  0.985
Data Source:  Reactome,STRINGDB
PRDX5
Tbio
Novelty:  0.00369421
Score:  0.902
Data Source:  STRINGDB
ATP5F1C
Tbio
Family:  Enzyme
Novelty:  0.07666564
Score:  0.896
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CCL17 measurement
1
1
1
86.5
mean platelet volume
3
1
3
85.4
platelet aggregation
1
1
1
82.8
3
1
1
1.1
70.2
lymphocyte count
2
1
2
66
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CCL17 measurement
1
86.5
mean platelet volume
3
85.4
platelet aggregation
1
82.8
1
1.1
70.2
lymphocyte count
2
66
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peroxiredoxin 3
741184
Macaque
peroxiredoxin 3
702882
Mouse
MGI:88034
11757
Rat
RGD:620040
64371
Dog
peroxiredoxin 3
477839
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peroxiredoxin 3
Macaque
peroxiredoxin 3
Mouse
Rat
Dog
peroxiredoxin 3
Publication Statistics
PubMed Score 297.01
PubMed score by year
PubTator Score 134.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title