Protein Summary
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and pl ...more
- ENST00000301522
- ENSP00000301522
- ENSG00000167815
- NKEFB
- TDPX1
- PRP
- TSA
- PRX2
- PTX1
- TPX1
- NKEFB
- PRXII
- TDPX1
- NKEF-B
- HEL-S-2a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 0.99 | ||
protein complex | 0.99 | ||
small molecule perturbation | 0.91 | ||
transcription factor perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 556.67 (req: < 5)
Gene RIFs: 117 (req: <= 3)
Antibodies: 490 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 556.67 (req: >= 5)
Gene RIFs: 117 (req: > 3)
Antibodies: 490 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (177)
FAM171A2
Novelty: 1.18763693
p_int: 0.998650376
p_ni: 0.001349616
p_wrong: 8e-9
Data Source: BioPlex
UBB
Novelty: 0.00661254
p_int: 0.997871572
p_ni: 0.002105889
p_wrong: 0.00002254
Score: 0.291
Data Source: BioPlex,STRINGDB
TXNDC9
Novelty: 0.00309772
p_int: 0.993002572
p_ni: 0.006997428
Score: 0.351
Data Source: BioPlex,STRINGDB
CCT2
Novelty: 0.01967139
p_int: 0.985184173
p_ni: 0.014815827
Score: 0.297
Data Source: BioPlex,STRINGDB
TCP1
Novelty: 0.00395241
p_int: 0.981502773
p_ni: 0.018497227
Score: 0.365
Data Source: BioPlex,STRINGDB
CCT6A
Novelty: 0.02368046
p_int: 0.971167258
p_ni: 0.028832742
Score: 0.254
Data Source: BioPlex,STRINGDB
CCT7
Novelty: 0.02247038
p_int: 0.968595061
p_ni: 0.031404939
Score: 0.201
Data Source: BioPlex,STRINGDB
CCT6B
Novelty: 0.28933315
p_int: 0.960839909
p_ni: 0.039160089
p_wrong: 2e-9
Score: 0.186
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (65)
Reactome (11)
WikiPathways (54)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | ||||
Reactome | Detoxification of Reactive Oxygen Species | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | ||||
Detoxification of Reactive Oxygen Species | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 4 | 6 | 6 | 98.2 | |||||
reticulocyte measurement | 3 | 4 | 5 | 97.2 | |||||
mean corpuscular hemoglobin concentration | 3 | 3 | 3 | 97 | |||||
reticulocyte count | 7 | 3 | 7 | 94.2 | |||||
erythrocyte count | 3 | 3 | 3 | 93.2 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular volume | 6 | 98.2 | |||||
reticulocyte measurement | 5 | 97.2 | |||||
mean corpuscular hemoglobin concentration | 3 | 97 | |||||
reticulocyte count | 7 | 94.2 | |||||
erythrocyte count | 3 | 93.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | peroxiredoxin 2 | VGNC:2281 | 468740 | |||||
Macaque | peroxiredoxin 2 | 716665 | ||||||
Mouse | MGI:109486 | 21672 | ||||||
Rat | RGD:3838 | 29338 | ||||||
Dog | peroxiredoxin 2 | VGNC:44951 | 100856470 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | peroxiredoxin 2 | |||||
Macaque | peroxiredoxin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | peroxiredoxin 2 | |||||
Publication Statistics
PubMed Score 556.67
PubMed score by year
PubTator Score 249.59
PubTator score by year
Related Publications
Text Mined References (154)
GeneRif Annotations (117)
Items per page:
0 of 0
PMID | Year | Title |
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