Tbio PRDX2 Peroxiredoxin-2

Protein Summary

Description

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

Uniprot Accession IDs

• P32119
• A8K0C0
• P31945
• P32118
• P35701
• Q6FHG4
• Q92763
• Q9UC23

Gene Name

• PRDX2

Ensembl ID

• ENST00000301522
• ENSP00000301522
• ENSG00000167815

Symbol

• NKEFB
• TDPX1
• PRP
• TSA
• PRX2
• PTX1
• TPX1
• NKEFB
• PRXII
• TDPX1
• NKEF-B
• HEL-S-2a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.99
protein complex	0.99
small molecule perturbation	0.91
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Peroxidase / Peroxiredoxin-2

DTO Classes

Protein / Enzyme / Oxidoreductase / Peroxidase / Peroxiredoxin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 556.67   (req: < 5)

Gene RIFs: 117   (req: <= 3)

Antibodies: 490   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 556.67   (req: >= 5)

Gene RIFs: 117   (req: > 3)

Antibodies: 490   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (177)

Explore Interacting Targets

1 – 10 of 177

• See Interactions on String-DB

TRAPPC12

Tbio

Novelty:  0.09847363

p_int:  0.999541872

p_ni:  0.000458128

Data Source:  BioPlex

FAM171A2

Tdark

Novelty:  1.18763693

p_int:  0.998650376

p_ni:  0.001349616

p_wrong:  8e-9

Data Source:  BioPlex

UBB

Tbio

Novelty:  0.00661254

p_int:  0.997871572

p_ni:  0.002105889

p_wrong:  0.00002254

Score:  0.291

Data Source:  BioPlex,STRINGDB

TXNDC9

Tbio

Novelty:  0.00309772

p_int:  0.993002572

p_ni:  0.006997428

Score:  0.351

Data Source:  BioPlex,STRINGDB

ANKRD40

Tdark

Novelty:  1.06633958

p_int:  0.989316198

p_ni:  0.010683801

Data Source:  BioPlex

CCT2

Tbio

Novelty:  0.01967139

p_int:  0.985184173

p_ni:  0.014815827

Score:  0.297

Data Source:  BioPlex,STRINGDB

TCP1

Tbio

Novelty:  0.00395241

p_int:  0.981502773

p_ni:  0.018497227

Score:  0.365

Data Source:  BioPlex,STRINGDB

CCT6A

Tbio

Novelty:  0.02368046

p_int:  0.971167258

p_ni:  0.028832742

Score:  0.254

Data Source:  BioPlex,STRINGDB

CCT7

Tbio

Novelty:  0.02247038

p_int:  0.968595061

p_ni:  0.031404939

Score:  0.201

Data Source:  BioPlex,STRINGDB

CCT6B

Tdark

Novelty:  0.28933315

p_int:  0.960839909

p_ni:  0.039160089

p_wrong:  2e-9

Score:  0.186

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (65)

Reactome (11)

WikiPathways (54)

Cellular responses to external stimuli (R-HSA-8953897)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	22 targets	R-HSA-8862803
Reactome	Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685
Reactome	Disease	1105 targets	R-HSA-1643685

Name	Explore in Pharos	Explore in Source
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	22 targets	R-HSA-8862803
Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685
Disease	1105 targets	R-HSA-1643685

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (2)

Components (3)

Processes (7)

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1 – 2 of 2

GO Term	Evidence	Assigned by
antioxidant activity	Inferred from Direct Assay (IDA)	UniProtKB
thioredoxin peroxidase activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (19)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	4	6	6		98.2
reticulocyte measurement	EFO_0010700	3	4	5		97.2
mean corpuscular hemoglobin concentration	EFO_0004528	3	3	3		97
reticulocyte count	EFO_0007986	7	3	7		94.2
erythrocyte count	EFO_0004305	3	3	3		93.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	6		98.2
reticulocyte measurement	EFO_0010700	5		97.2
mean corpuscular hemoglobin concentration	EFO_0004528	3		97
reticulocyte count	EFO_0007986	7		94.2
erythrocyte count	EFO_0004305	3		93.2

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Antioxidant
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Oxidoreductase
Peroxidase

GWAS Trait Find Similar Targets

No Header	No Header
blood metabolite measurement
body mass index
cognitive function measurement
erythrocyte count
HbA1c measurement
intelligence
lymphocyte percentage of leukocytes
mathematical ability
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	peroxiredoxin 2	VGNC:2281	468740
Macaque	peroxiredoxin 2		716665
Mouse	peroxiredoxin 2	MGI:109486	21672
Rat	peroxiredoxin 2	RGD:3838	29338
Dog	peroxiredoxin 2	VGNC:44951	100856470

Species	Name	OMA	EggNOG	Inparanoid
Chimp	peroxiredoxin 2
Macaque	peroxiredoxin 2
Mouse	peroxiredoxin 2
Rat	peroxiredoxin 2
Dog	peroxiredoxin 2

Publication Statistics

PubMed Score 556.67

PubMed score by year

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PubTator Score 249.59

PubTator score by year

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Related Publications

Text Mined References (154)

GeneRif Annotations (117)

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PMID	Year	Title