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Tbio
PRDM5
PR domain zinc finger protein 5

Protein Summary
Description
Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264808
  • ENSP00000264808
  • ENSG00000138738
  • ENST00000394435
  • ENSP00000377955
  • ENST00000428209
  • ENSP00000404832
  • ENST00000515109
  • ENSP00000422309

Symbol
  • PFM2
  • BCS2
  • PFM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.85
biological process
0.72
cell type or tissue
0.7
histone modification site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.3   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.3   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
CCDC77
Tdark
Novelty:  2.54727442
p_int:  0.999997082
p_ni:  0.000002732
p_wrong:  1.86e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
FAM102B
Tdark
Novelty:  1.44024802
p_int:  0.999996092
p_ni:  2.31e-7
p_wrong:  0.000003677
Score:  0.199
Data Source:  BioPlex,STRINGDB
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.999966395
p_ni:  0.000033605
Score:  0.172
Data Source:  BioPlex,STRINGDB
ZNF687
Tbio
Family:  TF
Novelty:  0.14707532
p_int:  0.999934639
p_ni:  0.000065361
Data Source:  BioPlex
THAP11
Tbio
Family:  TF
Novelty:  0.0679686
p_int:  0.999903714
p_ni:  0.000096164
p_wrong:  1.22e-7
Data Source:  BioPlex
TNRC18
Tdark
Novelty:  0.32654022
p_int:  0.999830216
p_ni:  0.000169759
p_wrong:  2.5e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
YBX2
Tbio
Family:  TF
Novelty:  0.01540247
p_int:  0.999420691
p_ni:  0.000570131
p_wrong:  0.000009178
Data Source:  BioPlex
ABT1
Tbio
Novelty:  0.05236553
p_int:  0.998819129
p_ni:  0.001180871
Data Source:  BioPlex
ZFP91
Tbio
Family:  TF
Novelty:  0.06937322
p_int:  0.996218108
p_ni:  0.00373402
p_wrong:  0.000047872
Data Source:  BioPlex
ZBTB4
Tbio
Family:  TF
Novelty:  0.06984344
p_int:  0.996203947
p_ni:  6.51e-7
p_wrong:  0.003795402
Score:  0.234
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
31.4
smoking status measurement
1
1
1
14.2
pulmonary function measurement
1
1
0
7.4
7.5
vital capacity
1
1
0
5.5
7.5
maximal voluntary ventilation
1
1
0
7.4
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
31.4
smoking status measurement
1
14.2
pulmonary function measurement
0
7.4
7.5
vital capacity
0
5.5
7.5
maximal voluntary ventilation
0
7.4
7.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 5
VGNC:12961
461462
Macaque
PR/SET domain 5
708790
Mouse
MGI:1918029
70779
Rat
RGD:1588700
689788
Dog
PR/SET domain 5
VGNC:54812
483850
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 5
Macaque
PR/SET domain 5
Mouse
Rat
Dog
PR/SET domain 5
Publication Statistics
PubMed Score 66.30
PubMed score by year
PubTator Score 30.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title