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Tbio
PRDM1
PR domain zinc finger protein 1

Protein Summary
Description
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369089
  • ENSP00000358085
  • ENSG00000057657
  • ENST00000369091
  • ENSP00000358087
  • ENST00000369096
  • ENSP00000358092

Symbol
  • BLIMP1
  • BLIMP1
  • PRDI-BF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
biological process
0.93
gene perturbation
0.93
microRNA
0.93
transcription factor
0.93


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 479.06   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 633   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 479.06   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
DPYSL3
Tbio
Family:  Enzyme
Novelty:  0.01284077
p_int:  0.998774196
p_ni:  0.00122577
p_wrong:  3.3e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
BMX
Tchem
Family:  Kinase
Novelty:  0.00383533
p_int:  0.981743669
p_ni:  0.018256331
Score:  0.24
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.974903452
p_ni:  0.025094795
p_wrong:  0.000001753
Score:  0.265
Data Source:  BioPlex,STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
p_int:  0.92510317
p_ni:  0.074896807
p_wrong:  2.3e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
UBE4A
Tbio
Novelty:  0.02576018
p_int:  0.800484439
p_ni:  0.198273473
p_wrong:  0.001242089
Score:  0.187
Data Source:  BioPlex,STRINGDB
DLG1
Tbio
Novelty:  0.0050926
p_int:  0.797736884
p_ni:  0.202262759
p_wrong:  3.57e-7
Score:  0.216
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.962
Data Source:  STRINGDB
PAX5
Tbio
Family:  TF
Novelty:  0.0012666
Score:  0.946
Data Source:  STRINGDB
IRF4
Tbio
Family:  TF
Novelty:  0.00192973
Score:  0.943
Data Source:  STRINGDB
BACH2
Tbio
Family:  TF
Novelty:  0.00932069
Score:  0.871
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Expression
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (36)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
0
1.2
81.6
balding measurement
1
2
2
81.4
3
2
0
1.1
76.9
3
3
1
1.2
69.3
lymphocyte count
2
1
2
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
81.6
balding measurement
2
81.4
0
1.1
76.9
1
1.2
69.3
lymphocyte count
2
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 1
VGNC:7905
462904
Macaque
PR/SET domain 1
696757
Mouse
MGI:99655
12142
Rat
RGD:1311765
309871
Dog
PR/SET domain 1
VGNC:44944
481947
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 1
Macaque
PR/SET domain 1
Mouse
Rat
Dog
PR/SET domain 1
Publication Statistics
PubMed Score 479.06
PubMed score by year
PubTator Score 298.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title