You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PRCP
Lysosomal Pro-X carboxypeptidase

Protein Summary
Description
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313010
  • ENSP00000317362
  • ENSG00000137509
  • ENST00000393399
  • ENSP00000377055

Symbol
  • PCP
  • PCP
  • HUMPCP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor binding site profile
0.91
histone modification site profile
0.82
tissue sample
0.74
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.42   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.42   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 324
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (117)
FBXO6
Tbio
Novelty:  0.02173918
p_int:  0.862796158
p_ni:  0.137203842
Score:  0.228
Data Source:  BioPlex,STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.791151575
p_ni:  0.208848425
Score:  0.19
Data Source:  BioPlex,STRINGDB
KLKB1
Tclin
Family:  Enzyme
Novelty:  0.00109438
Score:  0.963
Data Source:  Reactome,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.956
Data Source:  Reactome,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
Score:  0.938
Data Source:  Reactome,STRINGDB
ACE2
Tchem
Family:  Enzyme
Novelty:  0.00028408
Score:  0.924
Data Source:  STRINGDB
MEP1A
Tchem
Novelty:  0.01802936
Score:  0.914
Data Source:  STRINGDB
LAMP2
Tbio
Novelty:  0.00168009
Score:  0.911
Data Source:  STRINGDB
SURF4
Tbio
Novelty:  0.03230108
Score:  0.91
Data Source:  STRINGDB
LPCAT1
Tbio
Family:  Enzyme
Novelty:  0.01441133
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Name
Explore in Pharos
Explore in Source
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Immune System
Innate Immune System
Intrinsic Pathway of Fibrin Clot Formation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prolylcarboxypeptidase
VGNC:1042
451453
Macaque
prolylcarboxypeptidase
701305
Mouse
MGI:1919711
72461
Rat
RGD:1307842
293118
Dog
prolylcarboxypeptidase
VGNC:44943
476788
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prolylcarboxypeptidase
Macaque
prolylcarboxypeptidase
Mouse
Rat
Dog
prolylcarboxypeptidase
Publication Statistics
PubMed Score 157.42
PubMed score by year
PubTator Score 269.37
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title