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Tbio
PRCC
Proline-rich protein PRCC

Protein Summary
Description
May regulate cell cycle progression through interaction with MAD2L2. This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271526
  • ENSP00000271526
  • ENSG00000143294

Symbol
  • TPRC
  • TPRC
  • RCCP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
ligand (protein) perturbation
0.83
histone modification site profile
0.79
gene perturbation
0.76
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (248)
C19orf57
Tdark
Novelty:  1.59437078
p_int:  0.99987363
p_ni:  0.000123368
p_wrong:  0.000003002
Score:  0.193
Data Source:  BioPlex,STRINGDB
F11
Tchem
Family:  Enzyme
Novelty:  0.00169618
p_int:  0.99918109
p_ni:  0.000805081
p_wrong:  0.000013829
Score:  0.26
Data Source:  BioPlex,STRINGDB
TKTL2
Tbio
Family:  Enzyme
Novelty:  0.0915871
p_int:  0.996413906
p_ni:  0.003586049
p_wrong:  4.5e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
BCAM
Tbio
Novelty:  0.01697541
p_int:  0.986960952
p_ni:  0.013039046
p_wrong:  2e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
WRAP73
Tbio
Novelty:  0.25394934
p_int:  0.98461217
p_ni:  0.01538783
Score:  0.222
Data Source:  BioPlex,STRINGDB
FAF1
Tbio
Novelty:  0.01526275
p_int:  0.932522479
p_ni:  0.067477521
Score:  0.25
Data Source:  BioPlex,STRINGDB
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.922426404
p_ni:  0.077573596
Score:  0.916
Data Source:  BioPlex,STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
p_int:  0.883916951
p_ni:  0.116083049
Score:  0.177
Data Source:  BioPlex,STRINGDB
FKBP9
Tbio
Family:  Enzyme
Novelty:  0.16472204
p_int:  0.876115688
p_ni:  0.123884312
Score:  0.239
Data Source:  BioPlex,STRINGDB
CARM1
Tchem
Family:  Epigenetic
Novelty:  0.00623937
p_int:  0.83191475
p_ni:  0.16808525
Score:  0.153
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (104)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
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Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
3
5
89
mean platelet volume
4
1
4
87.6
platelet crit
2
2
2
73.8
lymphocyte count
1
1
1
58.4
autoimmune thyroid disease
1
1
0
1.1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
89
mean platelet volume
4
87.6
platelet crit
2
73.8
lymphocyte count
1
58.4
autoimmune thyroid disease
0
1.1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
papillary renal cell carcinoma (translocation-associated)
457405
Macaque
papillary renal cell carcinoma (translocation-associated)
718660
Mouse
MGI:2137738
94315
Rat
RGD:1309037
310687
Dog
papillary renal cell carcinoma (translocation-associated)
610063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
papillary renal cell carcinoma (translocation-associated)
Macaque
papillary renal cell carcinoma (translocation-associated)
Mouse
Rat
Dog
papillary renal cell carcinoma (translocation-associated)
Publication Statistics
PubMed Score 109.21
PubMed score by year
PubTator Score 186.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title