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Tbio
PRAME
Melanoma antigen preferentially expressed in tumors

Protein Summary
Description
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398741
  • ENSP00000381726
  • ENSG00000185686
  • ENST00000398743
  • ENSP00000381728
  • ENST00000402697
  • ENSP00000385198
  • ENST00000405655
  • ENSP00000384343
  • ENST00000539862
  • ENSP00000445097
  • ENSG00000275013
  • ENST00000543184
  • ENSP00000445675
  • ENST00000617728
  • ENSP00000484066
  • ENST00000626503
  • ENSP00000486485
  • ENST00000628830
  • ENSP00000486330

Symbol
  • MAPE
  • OIP4
  • MAPE
  • OIP4
  • CT130
  • OIP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
biological process
0.71
tissue sample
0.7
biological term
0.67
tissue
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.88   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.88   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
IFT81
Tbio
Novelty:  0.01610195
p_int:  0.99985574
p_ni:  0.000144259
p_wrong:  2e-9
Data Source:  BioPlex
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.999815525
p_ni:  0.000184092
p_wrong:  3.82e-7
Score:  0.419
Data Source:  BioPlex,STRINGDB
MLST8
Tbio
Novelty:  0.00423122
p_int:  0.997732474
p_ni:  0.002267372
p_wrong:  1.54e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
AZIN2
Tbio
Family:  Enzyme
Novelty:  0.00750311
p_int:  0.994400216
p_ni:  0.005599767
p_wrong:  1.7e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
QTRT1
Tbio
Family:  Enzyme
Novelty:  0.04387363
p_int:  0.986839625
p_ni:  0.012360019
p_wrong:  0.000800355
Score:  0.19
Data Source:  BioPlex,STRINGDB
EEF1D
Tbio
Novelty:  0.02480745
p_int:  0.985341224
p_ni:  0.014658776
Data Source:  BioPlex
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.979038401
p_ni:  0.020717756
p_wrong:  0.000243843
Data Source:  BioPlex
ZNF562
Tdark
Family:  TF
Novelty:  12.38372093
p_int:  0.976861728
p_ni:  0.022481821
p_wrong:  0.000656451
Score:  0.161
Data Source:  BioPlex,STRINGDB
GATD1
Tdark
Family:  Enzyme
Novelty:  0.40291197
p_int:  0.975326918
p_ni:  0.02227025
p_wrong:  0.002402832
Data Source:  BioPlex
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.975209563
p_ni:  0.024269417
p_wrong:  0.00052102
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
preferentially expressed antigen in melanoma
470260
Macaque
melanoma antigen preferentially expressed in tumors
700564
Dog
preferentially expressed antigen in melanoma
477552
Horse
melanoma antigen preferentially expressed in tumors
100061889
Cow
melanoma antigen preferentially expressed in tumors-like
789301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
preferentially expressed antigen in melanoma
Macaque
melanoma antigen preferentially expressed in tumors
Dog
preferentially expressed antigen in melanoma
Horse
melanoma antigen preferentially expressed in tumors
Cow
melanoma antigen preferentially expressed in tumors-like
Publication Statistics
PubMed Score 301.88
PubMed score by year
PubTator Score 145.67
PubTator score by year
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Related Publications
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PMID
Year
Title