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Tbio
PRAF2
PRA1 family protein 2

Protein Summary
Description
May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000553851
  • ENSP00000451962
  • ENSG00000243279

Symbol
  • JM4
  • Yip6a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.71
cell type or tissue
0.65
disease perturbation
0.62
small molecule perturbation
0.6
histone modification site profile
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.11   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.11   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.992752627
p_ni:  0.00724736
p_wrong:  1.3e-8
Score:  0.297
Data Source:  BioPlex,STRINGDB
MINDY2
Tbio
Novelty:  0.46783751
p_int:  0.984641119
p_ni:  0.015348137
p_wrong:  0.000010745
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.978860639
p_ni:  0.020408486
p_wrong:  0.000730875
Data Source:  BioPlex
HMOX2
Tchem
Family:  Enzyme
Novelty:  0.00180703
p_int:  0.959253283
p_ni:  0.040706905
p_wrong:  0.000039812
Data Source:  BioPlex
DLK1
Tchem
Novelty:  0.00212394
p_int:  0.931242911
p_ni:  0.068756692
p_wrong:  3.96e-7
Data Source:  BioPlex
LAMTOR1
Tbio
Novelty:  0.04952213
p_int:  0.929250036
p_ni:  0.070727027
p_wrong:  0.000022937
Data Source:  BioPlex
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.924332212
p_ni:  0.070930241
p_wrong:  0.004737547
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.908507612
p_ni:  0.089131599
p_wrong:  0.002360789
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.895646164
p_ni:  0.102561643
p_wrong:  0.001792194
Data Source:  BioPlex
VAC14
Tbio
Novelty:  0.02677738
p_int:  0.889417919
p_ni:  0.106714909
p_wrong:  0.003867172
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
45.5
mean arterial pressure
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
45.5
mean arterial pressure
1
1.8
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1859607
54637
Rat
RGD:1566287
367743
Dog
PRA1 domain family member 2
VGNC:44939
480912
Cow
PRA1 domain family member 2
VGNC:33283
508703
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
PRA1 domain family member 2
Cow
PRA1 domain family member 2
Publication Statistics
PubMed Score 30.11
PubMed score by year
PubTator Score 9.33
PubTator score by year
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Related Publications
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PMID
Year
Title