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Tdark
PRADC1
Protease-associated domain-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258083
  • ENSP00000258083
  • ENSG00000135617

Symbol
  • C2orf7
  • PAP21
  • PAP21
  • C2orf7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
disease perturbation
0.68
tissue sample
0.67
transcription factor binding site profile
0.66
kinase perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.3   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.3   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (11)
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.999704825
p_ni:  0.000274552
p_wrong:  0.000020623
Score:  0.183
Data Source:  BioPlex,STRINGDB
A2M
Tbio
Novelty:  0.00070446
p_int:  0.999320556
p_ni:  0.000409535
p_wrong:  0.000269909
Score:  0.187
Data Source:  BioPlex,STRINGDB
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.995512846
p_ni:  0.004080359
p_wrong:  0.000406796
Data Source:  BioPlex
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.877305443
p_ni:  0.119479398
p_wrong:  0.003215159
Data Source:  BioPlex
PRSS37
Tdark
Family:  Enzyme
Novelty:  0.40482351
Score:  0.651
Data Source:  STRINGDB
SFXN4
Tbio
Novelty:  0.1774204
Score:  0.569
Data Source:  STRINGDB
ZNF490
Tdark
Family:  TF
Novelty:  2.7619637
Score:  0.568
Data Source:  STRINGDB
FBXO41
Tbio
Novelty:  0.19719067
Score:  0.565
Data Source:  STRINGDB
CCDC18
Tdark
Novelty:  0.61246881
Score:  0.552
Data Source:  STRINGDB
NUDT7
Tdark
Family:  Enzyme
Novelty:  0.05817561
Score:  0.534
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
2
3
81.4
intelligence
2
5
3
6.2
65.5
glomerular filtration rate
1
1
1
47.7
self reported educational attainment
2
2
2
46.9
puberty onset measurement
1
1
1
17.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
3
81.4
intelligence
3
6.2
65.5
glomerular filtration rate
1
47.7
self reported educational attainment
2
46.9
puberty onset measurement
1
17.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protease associated domain containing 1
VGNC:10747
470405
Macaque
protease associated domain containing 1
706052
Mouse
MGI:1920577
73327
Rat
RGD:1583112
686393
Dog
protease associated domain containing 1
VGNC:44938
612337
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protease associated domain containing 1
Macaque
protease associated domain containing 1
Mouse
Rat
Dog
protease associated domain containing 1
Publication Statistics
PubMed Score 7.30
PubMed score by year
PubTator Score 1.10
PubTator score by year
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Related Publications
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PMID
Year
Title