Tbio PPWD1 Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Protein Summary

Description

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638).

Uniprot Accession IDs

• Q96BP3
• B4DWR9
• Q15002
• Q7KZ89

Gene Name

• PPWD1

Ensembl ID

• ENST00000261308
• ENSP00000261308
• ENSG00000113593
• ENST00000538977
• ENSP00000444496

Symbol

• KIAA0073

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
tissue sample	0.75
protein domain	0.73
disease perturbation	0.62
cell type or tissue	0.58

Protein Classes

PANTHER Classes

Protein / Isomerase / Peptidylprolyl Isomerase Domain And Wd Repeat-containing Protein 1

DTO Classes

Protein / Enzyme / Isomerase / Peptidylprolyl Isomerase Domain And Wd Repeat-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (203)

Explore Interacting Targets

1 – 10 of 203

• See Interactions on String-DB

SEC13

Tbio

Novelty:  0.00709413

p_int:  0.999992429

p_ni:  0.000007571

Score:  0.243

Data Source:  BioPlex,STRINGDB

ZNF232

Tdark

Family:  TF

Novelty:  0.68288358

p_int:  0.994103147

p_ni:  0.000213293

p_wrong:  0.00568356

Score:  0.195

Data Source:  BioPlex,STRINGDB

ZMYM6

Tdark

Novelty:  0.4933879

p_int:  0.993304155

p_ni:  0.005230929

p_wrong:  0.001464916

Data Source:  BioPlex

DHX16

Tbio

Family:  Enzyme

Novelty:  0.02678951

Score:  0.955

Data Source:  STRINGDB

CWC27

Tbio

Family:  Enzyme

Novelty:  0.15135654

Score:  0.952

Data Source:  STRINGDB

XAB2

Tbio

Novelty:  0.04104647

Score:  0.947

Data Source:  STRINGDB

CDC40

Tbio

Novelty:  0.03139044

Score:  0.944

Data Source:  STRINGDB

SF3A2

Tbio

Novelty:  0.03658692

Score:  0.942

Data Source:  STRINGDB

PPIL4

Tdark

Family:  Enzyme

Novelty:  0.3737992

Score:  0.941

Data Source:  STRINGDB

CWC25

Tdark

Novelty:  0.13727856

Score:  0.94

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

Metabolism of RNA (R-HSA-8953854)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (2)

Components (3)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cyclosporin A binding	Inferred from Direct Assay (IDA)	UniProtKB
peptidyl-prolyl cis-trans isomerase activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (1)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
feeling tense measurement	EFO_0009596	1	1	0	6	31.4

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1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
feeling tense measurement	EFO_0009596	0	6	31.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Isomerase
mRNA processing
mRNA splicing
Nucleus
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
feeling tense measurement

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	peptidylprolyl isomerase domain and WD repeat containing 1	VGNC:4135	743348
Macaque	peptidylprolyl isomerase domain and WD repeat containing 1		696267
Mouse	peptidylprolyl isomerase domain and WD repeat containing 1	MGI:2443069	238831
Rat	peptidylprolyl isomerase domain and WD repeat containing 1	RGD:1310204	294711
Dog	peptidylprolyl isomerase domain and WD repeat containing 1	VGNC:44932	478078

Species	Name	OMA	EggNOG	Inparanoid
Chimp	peptidylprolyl isomerase domain and WD repeat containing 1
Macaque	peptidylprolyl isomerase domain and WD repeat containing 1
Mouse	peptidylprolyl isomerase domain and WD repeat containing 1
Rat	peptidylprolyl isomerase domain and WD repeat containing 1
Dog	peptidylprolyl isomerase domain and WD repeat containing 1

Publication Statistics

PubMed Score 8.53

PubMed score by year

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PubTator Score 2.20

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (1)

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PMID	Year	Title