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Tdark
PPTC7
Protein phosphatase PTC7 homolog

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354300
  • ENSP00000346255
  • ENSG00000196850

Symbol
  • TAPP2C
  • TAPP2C
  • TA-PP2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
small molecule perturbation
0.73
microRNA
0.72
transcription factor binding site profile
0.7
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.11   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.11   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
RTN4IP1
Tbio
Family:  Enzyme
Novelty:  0.01274213
p_int:  0.999999996
p_ni:  4e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
TRMT2B
Tbio
Family:  Enzyme
Novelty:  0.12373575
p_int:  0.999999964
p_ni:  3.6e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
BNIP3
Tbio
Novelty:  0.00216392
p_int:  0.99984567
p_ni:  0.000152439
p_wrong:  0.000001891
Score:  0.188
Data Source:  BioPlex,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.999764479
p_ni:  0.000213002
p_wrong:  0.000022519
Data Source:  BioPlex
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.999631032
p_ni:  0.000368968
Score:  0.192
Data Source:  BioPlex,STRINGDB
ASF1A
Tchem
Novelty:  0.02544466
p_int:  0.999569254
p_ni:  0.000430746
Score:  0.186
Data Source:  BioPlex,STRINGDB
CD70
Tbio
Novelty:  0.00420393
p_int:  0.999287219
p_ni:  0.0006923
p_wrong:  0.000020481
Data Source:  BioPlex
TRMT61B
Tbio
Family:  Enzyme
Novelty:  0.32929047
p_int:  0.998988955
p_ni:  0.001011045
Score:  0.215
Data Source:  BioPlex,STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.997586796
p_ni:  0.002413204
Score:  0.238
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.995604899
p_ni:  0.004000166
p_wrong:  0.000394935
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
71.3
body height
1
1
1
48.5
risk-taking behaviour
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
71.3
body height
1
48.5
risk-taking behaviour
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PTC7 protein phosphatase homolog
VGNC:13350
736888
Mouse
MGI:2444593
320717
Rat
RGD:1310383
304488
Dog
PTC7 protein phosphatase homolog
VGNC:44931
100855437
Horse
PTC7 protein phosphatase homolog
VGNC:21799
100058244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PTC7 protein phosphatase homolog
Mouse
Rat
Dog
PTC7 protein phosphatase homolog
Horse
PTC7 protein phosphatase homolog
Publication Statistics
PubMed Score 4.11
PubMed score by year
PubTator Score 0.79
PubTator score by year
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Related Publications
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PMID
Year
Title